FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003251509> ?p ?o ?g. }

• W2003251509 endingPage "1738" @default.
• W2003251509 startingPage "1731" @default.
• W2003251509 abstract "Leptin regulates food intake and other activities through its hypothalamic receptor. Leptin receptors are also found in other organs, including the ovary. Direct effects of leptin in ovarian steroid production were studied in primary rat granulosa cells and in rat and human granulosa cell lines. Leptin (0.6-18 nM) suppressed ovarian steroid synthesis costimulated by FSH and dexamethasone. Production of pregnenolone, progesterone, and 20alpha-hydroxy-4-pregnen-3-one was inhibited by leptin. This inhibition was due at least in part to reduced expression of adrenodoxin, a component of the P450scc system enzyme. Costimulation of progesterone production by forskolin and dexamethasone was also inhibited by leptin, whereas the forskolin-induced cAMP production was not affected. We find that leptin induces c-Jun expression and attenuates the transcriptional activity of the glucocorticoid receptor (GR) in granulosa cells. Elevation of c-Jun expression by other means, e.g. 12-O tetradecanoyl-phorbol-13-acetate or transfecting with a c-Jun expression vector, abolished the transcriptional activity of the GR. A leptin-induced elevation of c-Jun modulates the transcriptional activity of the GR, possibly leading to the observed attenuation of steroidogenesis. It was recently shown that glucocorticoids stimulate leptin expression in vivo, which in turn, inhibits cortisol synthesis. A direct action of leptin on the ovary is an additional element of a regulatory network that maintains the homeostasis of steroid production." @default.
• W2003251509 created "2016-06-24" @default.
• W2003251509 creator A5004647809 @default.
• W2003251509 creator A5017021161 @default.
• W2003251509 creator A5060020804 @default.
• W2003251509 creator A5065443593 @default.
• W2003251509 creator A5084783108 @default.
• W2003251509 creator A5086856217 @default.
• W2003251509 date "1999-04-01" @default.
• W2003251509 modified "2023-10-06" @default.
• W2003251509 title "Leptin Modulates the Glucocorticoid-Induced Ovarian Steroidogenesis¹" @default.
• W2003251509 cites W1527082041 @default.
• W2003251509 cites W1980722886 @default.
• W2003251509 cites W1984021794 @default.
• W2003251509 cites W1985603777 @default.
• W2003251509 cites W1987557547 @default.
• W2003251509 cites W1989434784 @default.
• W2003251509 cites W1990307219 @default.
• W2003251509 cites W1993983676 @default.
• W2003251509 cites W1997157145 @default.
• W2003251509 cites W1999159727 @default.
• W2003251509 cites W2003846819 @default.
• W2003251509 cites W2006592185 @default.
• W2003251509 cites W2016994959 @default.
• W2003251509 cites W2021725988 @default.
• W2003251509 cites W2022132193 @default.
• W2003251509 cites W2025846514 @default.
• W2003251509 cites W2027360957 @default.
• W2003251509 cites W2027581733 @default.
• W2003251509 cites W2036224418 @default.
• W2003251509 cites W2040151918 @default.
• W2003251509 cites W2047490631 @default.
• W2003251509 cites W2049408696 @default.
• W2003251509 cites W2055956383 @default.
• W2003251509 cites W2066611818 @default.
• W2003251509 cites W2074728872 @default.
• W2003251509 cites W2075767463 @default.
• W2003251509 cites W2077037708 @default.
• W2003251509 cites W2082296248 @default.
• W2003251509 cites W2090977677 @default.
• W2003251509 cites W2091069239 @default.
• W2003251509 cites W2095308289 @default.
• W2003251509 cites W2112169793 @default.
• W2003251509 cites W2112972847 @default.
• W2003251509 cites W2117304682 @default.
• W2003251509 cites W2126757571 @default.
• W2003251509 cites W2135801208 @default.
• W2003251509 cites W2137736712 @default.
• W2003251509 cites W2144206181 @default.
• W2003251509 cites W2147452643 @default.
• W2003251509 cites W2147788805 @default.
• W2003251509 cites W2148844770 @default.
• W2003251509 cites W2149347375 @default.
• W2003251509 cites W2151304633 @default.
• W2003251509 cites W2154664381 @default.
• W2003251509 cites W2158838288 @default.
• W2003251509 cites W2161187682 @default.
• W2003251509 cites W2165101701 @default.
• W2003251509 cites W227580377 @default.
• W2003251509 cites W2505579966 @default.
• W2003251509 doi "https://doi.org/10.1210/endo.140.4.6614" @default.
• W2003251509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10098510" @default.
• W2003251509 hasPublicationYear "1999" @default.
• W2003251509 type Work @default.
• W2003251509 sameAs 2003251509 @default.
• W2003251509 citedByCount "74" @default.
• W2003251509 countsByYear W20032515092012 @default.
• W2003251509 countsByYear W20032515092013 @default.
• W2003251509 countsByYear W20032515092014 @default.
• W2003251509 countsByYear W20032515092015 @default.
• W2003251509 countsByYear W20032515092016 @default.
• W2003251509 countsByYear W20032515092017 @default.
• W2003251509 countsByYear W20032515092018 @default.
• W2003251509 countsByYear W20032515092019 @default.
• W2003251509 countsByYear W20032515092021 @default.
• W2003251509 countsByYear W20032515092022 @default.
• W2003251509 countsByYear W20032515092023 @default.
• W2003251509 crossrefType "journal-article" @default.
• W2003251509 hasAuthorship W2003251509A5004647809 @default.
• W2003251509 hasAuthorship W2003251509A5017021161 @default.
• W2003251509 hasAuthorship W2003251509A5060020804 @default.
• W2003251509 hasAuthorship W2003251509A5065443593 @default.
• W2003251509 hasAuthorship W2003251509A5084783108 @default.
• W2003251509 hasAuthorship W2003251509A5086856217 @default.
• W2003251509 hasBestOaLocation W20032515091 @default.
• W2003251509 hasConcept C126322002 @default.
• W2003251509 hasConcept C134018914 @default.
• W2003251509 hasConcept C14372207 @default.
• W2003251509 hasConcept C170493617 @default.
• W2003251509 hasConcept C185592680 @default.
• W2003251509 hasConcept C2778324911 @default.
• W2003251509 hasConcept C2779276759 @default.
• W2003251509 hasConcept C2780613262 @default.
• W2003251509 hasConcept C2780841215 @default.
• W2003251509 hasConcept C511355011 @default.
• W2003251509 hasConcept C59493245 @default.
• W2003251509 hasConcept C71924100 @default.
• W2003251509 hasConcept C86803240 @default.

• next