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- W2003252279 abstract "<h3>Objective:</h3> To determine if a pressure dressing containing fibrinogen and thrombin could provide more effective control of arterial hemorrhage than a pressure dressing alone in an animal model of arterial injury. <h3>Design:</h3> Randomized acute (nonsurvival) experiment in swine. <h3>Setting:</h3> Federal biomedical research institute. <h3>Animals:</h3> Six anesthetized Yorkshire swine. <h3>Interventions:</h3> Uncontrolled arterial hemorrhage was induced in anesthetized swine by creating femoral artery lacerations. Hemorrhage was controlled by a gauze bandage containing fibrinogen and thrombin, applied with 1 minute of 3.5-kg pressure. The dressings were left in place for 1 hour after the pressure was removed. The contralateral limbs received identical treatment with plain gauze dressings. <h3>Main Outcome Measures:</h3> Total blood loss, mean arterial pressure, and mortality were measured after 1 hour. <h3>Results:</h3> After 1 hour, blood loss in the fibrin bandage group was 123±48 mL, compared with 734±134 mL in the control group (<i>P</i>=.0022). In the group treated with the fibrin bandages, there was no significant decrease in the mean arterial pressure after arterial laceration. In contrast, there was a decrease of 30 mm Hg in the group treated with gauze dressings alone. There was no animal mortality during the study period. <h3>Conclusions:</h3> Bandages containing fibrinogen and thrombin significantly reduced the amount of blood loss and allowed mean arterial pressures to be maintained in animals with uncontrolled hemorrhage from femoral artery lacerations. A hemostatic bandage may be an important adjuvant for controlling severe extremity hemorrhage in the prehospital setting. (Arch Surg. 1995;130:420-422)" @default.
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- W2003252279 date "1995-04-01" @default.
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- W2003252279 title "Efficacy of a Fibrin Hemostatic Bandage in Controlling Hemorrhage From Experimental Arterial Injuries" @default.
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- W2003252279 doi "https://doi.org/10.1001/archsurg.1995.01430040082018" @default.
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