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• W2003252842 abstract "Since the transcription factor Zfhep is expressed in somatotropes and binds the rat growth hormone (rGH) gene T3-response element (TRE), we investigated whether Zfhep regulates the response of this gene to T3. In cotransfection experiments, Zfhep did not regulate the native rGH promoter in the absence of T3. However, Zfhep repressed T3-mediated activation significantly in either GH(3) or JEG-3 cells. Up to 70% repression was mediated through the rGH TRE in a heterologous promoter (thymidine kinase), but was not observed with the idealized DR4 or chicken lysozyme F2 TREs. Zfhep apparently does not repress T3-mediated activation simply by competition for binding to DNA since the C-terminal DNA-binding domain of Zfhep (which is sufficient for DNA-binding) is not sufficient for repression and since cotransfection of excess thyroid hormone receptor (TR) did not prevent repression by Zfhep. These data indicate that the rGH TRE is a composite element that can integrate Zfhep and T3 regulation." @default.
• W2003252842 created "2016-06-24" @default.
• W2003252842 creator A5051338193 @default.
• W2003252842 creator A5055741601 @default.
• W2003252842 creator A5080246031 @default.
• W2003252842 date "2001-07-01" @default.
• W2003252842 modified "2023-09-23" @default.
• W2003252842 title "T3-activation of the rat growth hormone gene is inhibited by a zinc finger/homeodomain protein" @default.
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• W2003252842 doi "https://doi.org/10.1016/s0303-7207(01)00531-7" @default.
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