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- W2003253108 abstract "We describe a randomized, double-blind, placebo-controlled, crossover trial with spiramycin in a single patient with aquired immune deficiency syndrome (AIDS) and a severe secretory diarrhea caused by cryptosporidium. Spiramycin, a potentially harmful antibiotic, had no clinical or microbiological effect in this patient. The application of the single patient (N of 1) trial to common clinical problems is a simple way to analyze the value of different therapeutic approaches. The time-consuming, expensive, multi-patient trial with ultimate extrapolation to the individual patient can be avoided. Single-patient trials can influence management and improve patient care and have potentially wide use in patients with gastrointestinal disease." @default.
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- W2003253108 date "1987-12-01" @default.
- W2003253108 modified "2023-09-24" @default.
- W2003253108 title "Treatment of Cryptosporidiosis with Spiramycin in AIDS" @default.
- W2003253108 doi "https://doi.org/10.1097/00004836-198712000-00005" @default.
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