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- W2003258995 abstract "Abstract Charcoal treatment (NORIT A) at pH 3 isolated hitherto unidentified endogenous compounds from uremic serum. These compounds were responsible for reduced binding of chloramphenicol to proteins in uremic patients. After treatment of uremic sera with NORIT, differences in the binding of chloramphenicol to serum proteins in healthy individuals and in uremic patients disappeared. The endogenous compounds were isolated from NORIT by elution using a mixture of 0.1 N HC 1 and ethanol (1:1). Eluates were then incubated with control serum for 2 hr at 37°C. The binding of chloramphenicol to control serum proteins decreased when eluates from uremie sera were added (P" @default.
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- W2003258995 date "1979-10-01" @default.
- W2003258995 modified "2023-10-16" @default.
- W2003258995 title "The effect of endogenous compounds, isolated from sera of uremic patients, on chloramphenicol binding to proteins" @default.
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- W2003258995 doi "https://doi.org/10.1016/0006-2952(79)90587-2" @default.
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