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- W2003261639 abstract "Heat-shock proteins (Hsps) are increasingly being implicated in aging phenotypes and control of life span across species. They are targets of the conserved heat-shock factor and insulin/IGF1-like signaling pathways that affect life span and aging phenotypes. Hsps are expressed in tissue-specific and disease-specific patterns during aging, and their level of expression and induction by stress correlates with and, in some instances, predicts life span. In model organisms, Hsps have been shown to increase life span and ameliorate aging-associated proteotoxicity. Finally, Hsps have emerged as key components in regulating aging-related cellular phenotypes, including cell senescence, apoptosis and cancer. The Hsps, therefore, provide a metric of individual stress and aging and are potential targets for interventions in aging and aging-related diseases." @default.
- W2003261639 created "2016-06-24" @default.
- W2003261639 creator A5033863027 @default.
- W2003261639 date "2009-07-01" @default.
- W2003261639 modified "2023-10-17" @default.
- W2003261639 title "Hsps and aging" @default.
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- W2003261639 doi "https://doi.org/10.1016/j.tem.2008.12.005" @default.
- W2003261639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3835556" @default.
- W2003261639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19394247" @default.
- W2003261639 hasPublicationYear "2009" @default.
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