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• W2003264562 abstract "The notochord is one of the defining features of chordates. The ascidian notochord is a rod like structure consisting of a single row of 40 cells. The anterior 32 `primary' notochord cells arise from the A-line (anterior vegetal)blastomeres of the eight-cell stage embryo, whereas the posterior 8`secondary' notochord cells arise from the B-line (posterior vegetal)blastomeres of the eight-cell stage embryo. Specification of notochord precursors within these two lineages occurs in a spatially and temporally distinct manner. We show that specification of the secondary but not the primary notochord in Ciona intestinalis requires a relay mechanism involving two signalling pathways. First, we show evidence that acquisition of secondary notochord fate is dependent upon lateral Nodal signalling sources,situated in the adjacent b-line animal cells. Expression of the notochord specific gene Ci-Brachyury in the secondary notochord precursor was downregulated following selective inhibition of Nodal signal reception in B-line derivatives and also, strikingly, following selective inhibition of Nodal signal reception in A-line cell derivatives. Within the A-line, Nodal signals are required for localised expression of Delta2, which encodes a divergent form of Delta ligand. Using four distinct reagents to inhibit Delta2/Notch signals, we showed that Delta2 signalling from A-line cells, which activates the Notch/Su(H) pathway in adjacent B-line cells, is required for specification of the secondary notochord precursor. We propose a model whereby laterally produced Nodal acts to specify the secondary notochord precursor both directly in the B-line cells and via Delta2 induction in adjacent A-line cells." @default.
• W2003264562 created "2016-06-24" @default.
• W2003264562 creator A5025601757 @default.
• W2003264562 creator A5041742217 @default.
• W2003264562 date "2006-08-01" @default.
• W2003264562 modified "2023-10-14" @default.
• W2003264562 title "A signalling relay involving Nodal and Delta ligands acts during secondary notochord induction in<i>Ciona</i>embryos" @default.
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• W2003264562 doi "https://doi.org/10.1242/dev.02466" @default.
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