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- W2003265283 abstract "The convoluted cortex of primates is instantly recognizable in its principal morphologic features, yet puzzling in its complex finer structure. Various hypotheses have been proposed about the mechanisms of its formation. Based on the analysis of databases of quantitative architectonic and connection data for primate prefrontal cortices, we offer support for the hypothesis that tension exerted by corticocortical connections is a significant factor in shaping the cerebral cortical landscape. Moreover, forces generated by cortical folding influence laminar morphology, and appear to have a previously unsuspected impact on cellular migration during cortical development. The evidence for a significant role of mechanical factors in cortical morphology opens the possibility of constructing computational models of cortical development based on physical principles. Such models are particularly relevant for understanding the relationship of cortical morphology to the connectivity of normal brains, and structurally altered brains in diseases of developmental origin, such as schizophrenia and autism." @default.
- W2003265283 created "2016-06-24" @default.
- W2003265283 creator A5014167212 @default.
- W2003265283 creator A5045659246 @default.
- W2003265283 date "2006-03-24" @default.
- W2003265283 modified "2023-10-16" @default.
- W2003265283 title "Role of Mechanical Factors in the Morphology of the Primate Cerebral Cortex" @default.
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- W2003265283 doi "https://doi.org/10.1371/journal.pcbi.0020022" @default.
- W2003265283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1409812" @default.
- W2003265283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16557292" @default.
- W2003265283 hasPublicationYear "2006" @default.
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