Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003265575> ?p ?o ?g. }
- W2003265575 abstract "Rats avoid intake of a saccharin cue when paired with a drug of abuse. While this is true for most subjects, the degree of avoidance of the drug-paired cue depends upon many factors including an individual rat's preference for rewards. That said, the direction of this effect is complex. For example, reward-preferring Lewis rats exhibit greater cocaine-induced avoidance of a saccharin cue relative to Fischer 344 rats; while reward-preferring mice that overexpress ΔFosB (NSE-tTA × TetOp-ΔFosB) exhibit less avoidance of the drug-paired taste cue compared to controls. The aim here was to use two strains of commonly used mice, C57BL/6J and DBA/2J, to determine whether known differences in sensitivity to rewards will facilitate or attenuate drug-induced suppression of intake of a drug-paired taste cue. The results of Experiment 1 demonstrate that C57BL/6J mice, compared with DBA/2J mice, exhibit attenuated suppression of saccharin intake when it is paired with cocaine. The results of Experiment 2 demonstrate that strain differences in impulsivity are not likely to account for these differences. It is proposed that, while the C57BL/6J mice typically are more responsive to drug, they also are more responsive to natural rewards (in this case saccharin), and the stronger preference for saccharin serves to militate against drug." @default.
- W2003265575 created "2016-06-24" @default.
- W2003265575 creator A5002156576 @default.
- W2003265575 creator A5019504464 @default.
- W2003265575 creator A5047766021 @default.
- W2003265575 date "2013-01-01" @default.
- W2003265575 modified "2023-10-01" @default.
- W2003265575 title "Compared with DBA/2J mice, C57BL/6J mice demonstrate greater preference for saccharin and less avoidance of a cocaine-paired saccharin cue." @default.
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- W2003265575 doi "https://doi.org/10.1037/a0032402" @default.
- W2003265575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3967761" @default.
- W2003265575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23544599" @default.