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• W2003265648 abstract "To evaluate whether lithium treatment has been overvalued and may be no longer as effective as formerly, we reviewed published reports on long-term lithium treatment (1970-1996) as well as analyzing its clinical effects on 360 patients with DSM-IV bipolar disorder who entered into lithium maintenance monotherapy after 1970. Neither reported recurrence rates nor average proportions of time ill nor patient improvement of 50% or more during lithium maintenance therapy in a stable clinic setting has changed significantly since the 1970s. Unfavorable results in some settings may reflect accumulation over time of patients with complex, less treatment-responsive illnesses. Lithium is unmatched in research support for long-term clinical effectiveness against morbidity and mortality associated with depression or mania in bipolar I and II disorders. Data evaluated herein did not support suggestions that benefits of lithium have been exaggerated in the past or have been lost recently." @default.
• W2003265648 created "2016-06-24" @default.
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• W2003265648 date "2000-02-01" @default.
• W2003265648 modified "2023-09-23" @default.
• W2003265648 title "Does Lithium Treatment Still Work?" @default.
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• W2003265648 doi "https://doi.org/10.1001/archpsyc.57.2.187" @default.
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