Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003266871> ?p ?o ?g. }
- W2003266871 endingPage "624" @default.
- W2003266871 startingPage "613" @default.
- W2003266871 abstract "Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively. Disruptors of the cytoskeleton (microfilaments, microtubules, and intermediate filaments) markedly attenuated the hyperalgesia in rat paws caused by injection of epinephrine or its downstream mediators. In contrast, the hyperalgesia induced by PGE(2) or its mediators was not affected by any of the cytoskeletal disruptors. These effects were mimicked in vitro, as measured by enhancement of the tetrodotoxin-resistant sodium current. When PGE(2) hyperalgesia was shifted to dependence on PKCepsilon and ERK as well as PKA, as when the tissue is primed by prior treatment with carrageenan, it too became dependent on an intact cytoskeleton. Thus, inflammatory mediator-induced mechanical hyperalgesia was differentially dependent on the cytoskeleton such that cytoskeletal dependence correlated with mediation by PKCepsilon and ERK." @default.
- W2003266871 created "2016-06-24" @default.
- W2003266871 creator A5033208393 @default.
- W2003266871 creator A5037181353 @default.
- W2003266871 creator A5037505930 @default.
- W2003266871 creator A5054823580 @default.
- W2003266871 date "2003-08-01" @default.
- W2003266871 modified "2023-10-14" @default.
- W2003266871 title "Role of the Sensory Neuron Cytoskeleton in Second Messenger Signaling for Inflammatory Pain" @default.
- W2003266871 cites W111392919 @default.
- W2003266871 cites W1507084693 @default.
- W2003266871 cites W1526407692 @default.
- W2003266871 cites W1528756081 @default.
- W2003266871 cites W1538619419 @default.
- W2003266871 cites W1551027803 @default.
- W2003266871 cites W1552443285 @default.
- W2003266871 cites W1566814755 @default.
- W2003266871 cites W1576381397 @default.
- W2003266871 cites W1576399086 @default.
- W2003266871 cites W1594268777 @default.
- W2003266871 cites W1709837271 @default.
- W2003266871 cites W1883732752 @default.
- W2003266871 cites W1905918448 @default.
- W2003266871 cites W1917968600 @default.
- W2003266871 cites W1954419182 @default.
- W2003266871 cites W1954733039 @default.
- W2003266871 cites W1956175627 @default.
- W2003266871 cites W1963522960 @default.
- W2003266871 cites W1964816489 @default.
- W2003266871 cites W1965467117 @default.
- W2003266871 cites W1971642414 @default.
- W2003266871 cites W1971754431 @default.
- W2003266871 cites W1971839532 @default.
- W2003266871 cites W1973556415 @default.
- W2003266871 cites W1978939719 @default.
- W2003266871 cites W1980437934 @default.
- W2003266871 cites W1983434348 @default.
- W2003266871 cites W1984203003 @default.
- W2003266871 cites W1990512833 @default.
- W2003266871 cites W1990583167 @default.
- W2003266871 cites W1997089381 @default.
- W2003266871 cites W1998899274 @default.
- W2003266871 cites W2000431527 @default.
- W2003266871 cites W2004637463 @default.
- W2003266871 cites W2006006247 @default.
- W2003266871 cites W2008118704 @default.
- W2003266871 cites W2009249382 @default.
- W2003266871 cites W2009930457 @default.
- W2003266871 cites W2010731773 @default.
- W2003266871 cites W2012652910 @default.
- W2003266871 cites W2012978268 @default.
- W2003266871 cites W2014211428 @default.
- W2003266871 cites W2030149988 @default.
- W2003266871 cites W2034056966 @default.
- W2003266871 cites W2036291551 @default.
- W2003266871 cites W2038064303 @default.
- W2003266871 cites W2039365326 @default.
- W2003266871 cites W2041279687 @default.
- W2003266871 cites W2042733728 @default.
- W2003266871 cites W2057211153 @default.
- W2003266871 cites W2059640700 @default.
- W2003266871 cites W2064356157 @default.
- W2003266871 cites W2068174068 @default.
- W2003266871 cites W2073127574 @default.
- W2003266871 cites W2081883648 @default.
- W2003266871 cites W2098588948 @default.
- W2003266871 cites W2102417288 @default.
- W2003266871 cites W2105493663 @default.
- W2003266871 cites W2118977349 @default.
- W2003266871 cites W2123881551 @default.
- W2003266871 cites W2128490730 @default.
- W2003266871 cites W2130851152 @default.
- W2003266871 cites W2132079516 @default.
- W2003266871 cites W2134814434 @default.
- W2003266871 cites W2140975775 @default.
- W2003266871 cites W2143743192 @default.
- W2003266871 cites W2148281583 @default.
- W2003266871 cites W2151113545 @default.
- W2003266871 cites W2153287457 @default.
- W2003266871 cites W2159242529 @default.
- W2003266871 cites W2165902043 @default.
- W2003266871 cites W2261997701 @default.
- W2003266871 cites W2285775472 @default.
- W2003266871 cites W2416320441 @default.
- W2003266871 cites W2417758924 @default.
- W2003266871 cites W2419373237 @default.
- W2003266871 cites W4246845501 @default.
- W2003266871 cites W93019692 @default.
- W2003266871 doi "https://doi.org/10.1016/s0896-6273(03)00473-2" @default.
- W2003266871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12925276" @default.
- W2003266871 hasPublicationYear "2003" @default.
- W2003266871 type Work @default.
- W2003266871 sameAs 2003266871 @default.
- W2003266871 citedByCount "120" @default.
- W2003266871 countsByYear W20032668712012 @default.
- W2003266871 countsByYear W20032668712013 @default.
- W2003266871 countsByYear W20032668712014 @default.
- W2003266871 countsByYear W20032668712015 @default.