Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003269554> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2003269554 endingPage "531" @default.
- W2003269554 startingPage "529" @default.
- W2003269554 abstract "Apoptosis is an ordered cascade of enzymatic events that culminates in cell death and the cleavage of DNA into characteristic nucleosomal fragments. It is operative during embryonic development and, during adult life, plays a key role in various physiological processes, such as tissue remodeling and execution and regulation of the immune response. The consequences of inappropriate apoptotic responses are profound; for example, the failure of cells to initiate apoptosis in response to DNA damage has been implicated in the development and progression of cancer, whereas inappropriate activation of apoptosis is thought to be a contributing factor in Alzheimer's disease and Parkinson's disease. Rigorous signaling requirements and a complex network of inhibitory molecules maintain tight control of the apoptotic process, while permitting rapid and effective responses to diverse extracellular and intracellular signals. Growth-factor withdrawal, specific peptide hormones (e.g., tumor necrosis factor α, Fas ligand, and TRAIL), changes in intracellular or extracellular calcium, drugs (e.g., staurosporine and phorbol esters), DNA damage, and mitochondrial poisons can all induce apoptosis, with each of these triggers activating a different portion of the pathway. As our knowledge of the apoptotic cell death cascade increases, it is becoming apparent that the system is more complex than first thought. In a recent issue of PNAS, Khaled and colleagues (1) have addressed how cells might accomplish this fine-tuning of the apoptosis cascade by analyzing the regulation of the proapoptotic molecule Bax in response to the withdrawal of growth factors." @default.
- W2003269554 created "2016-06-24" @default.
- W2003269554 creator A5075769599 @default.
- W2003269554 creator A5086393033 @default.
- W2003269554 date "2000-01-18" @default.
- W2003269554 modified "2023-10-13" @default.
- W2003269554 title "Bax-induced apoptotic cell death" @default.
- W2003269554 cites W1624001120 @default.
- W2003269554 cites W1662899239 @default.
- W2003269554 cites W1970941018 @default.
- W2003269554 cites W1976441097 @default.
- W2003269554 cites W2013319326 @default.
- W2003269554 cites W2014586657 @default.
- W2003269554 cites W2030573603 @default.
- W2003269554 cites W2049648341 @default.
- W2003269554 cites W2050477129 @default.
- W2003269554 cites W2062853648 @default.
- W2003269554 cites W2065333640 @default.
- W2003269554 cites W2072140726 @default.
- W2003269554 cites W2073028327 @default.
- W2003269554 cites W2081194139 @default.
- W2003269554 cites W2114001234 @default.
- W2003269554 cites W2134872883 @default.
- W2003269554 cites W2140967934 @default.
- W2003269554 cites W2158730778 @default.
- W2003269554 cites W227887930 @default.
- W2003269554 cites W2320244329 @default.
- W2003269554 doi "https://doi.org/10.1073/pnas.97.2.529" @default.
- W2003269554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/33959" @default.
- W2003269554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10639111" @default.
- W2003269554 hasPublicationYear "2000" @default.
- W2003269554 type Work @default.
- W2003269554 sameAs 2003269554 @default.
- W2003269554 citedByCount "205" @default.
- W2003269554 countsByYear W20032695542012 @default.
- W2003269554 countsByYear W20032695542013 @default.
- W2003269554 countsByYear W20032695542014 @default.
- W2003269554 countsByYear W20032695542015 @default.
- W2003269554 countsByYear W20032695542016 @default.
- W2003269554 countsByYear W20032695542017 @default.
- W2003269554 countsByYear W20032695542018 @default.
- W2003269554 countsByYear W20032695542019 @default.
- W2003269554 countsByYear W20032695542020 @default.
- W2003269554 countsByYear W20032695542021 @default.
- W2003269554 countsByYear W20032695542022 @default.
- W2003269554 countsByYear W20032695542023 @default.
- W2003269554 crossrefType "journal-article" @default.
- W2003269554 hasAuthorship W2003269554A5075769599 @default.
- W2003269554 hasAuthorship W2003269554A5086393033 @default.
- W2003269554 hasBestOaLocation W20032695542 @default.
- W2003269554 hasConcept C185592680 @default.
- W2003269554 hasConcept C190283241 @default.
- W2003269554 hasConcept C31573885 @default.
- W2003269554 hasConcept C54355233 @default.
- W2003269554 hasConcept C70721500 @default.
- W2003269554 hasConcept C86803240 @default.
- W2003269554 hasConcept C95444343 @default.
- W2003269554 hasConceptScore W2003269554C185592680 @default.
- W2003269554 hasConceptScore W2003269554C190283241 @default.
- W2003269554 hasConceptScore W2003269554C31573885 @default.
- W2003269554 hasConceptScore W2003269554C54355233 @default.
- W2003269554 hasConceptScore W2003269554C70721500 @default.
- W2003269554 hasConceptScore W2003269554C86803240 @default.
- W2003269554 hasConceptScore W2003269554C95444343 @default.
- W2003269554 hasIssue "2" @default.
- W2003269554 hasLocation W20032695541 @default.
- W2003269554 hasLocation W20032695542 @default.
- W2003269554 hasLocation W20032695543 @default.
- W2003269554 hasLocation W20032695544 @default.
- W2003269554 hasOpenAccess W2003269554 @default.
- W2003269554 hasPrimaryLocation W20032695541 @default.
- W2003269554 hasRelatedWork W1234816868 @default.
- W2003269554 hasRelatedWork W1565632507 @default.
- W2003269554 hasRelatedWork W1987695408 @default.
- W2003269554 hasRelatedWork W19916217 @default.
- W2003269554 hasRelatedWork W2003720298 @default.
- W2003269554 hasRelatedWork W2073254770 @default.
- W2003269554 hasRelatedWork W2074148448 @default.
- W2003269554 hasRelatedWork W2145626047 @default.
- W2003269554 hasRelatedWork W2151098840 @default.
- W2003269554 hasRelatedWork W2594560619 @default.
- W2003269554 hasVolume "97" @default.
- W2003269554 isParatext "false" @default.
- W2003269554 isRetracted "false" @default.
- W2003269554 magId "2003269554" @default.
- W2003269554 workType "article" @default.