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- W2003269888 abstract "A fractal analysis is made of antigen-antibody binding kinetics in various biosensor applications reported in the literature. Both sensor configurations are considered, wherein (a) the antigen is in solution and the antibody is immobilized on the fibre-optic surface, and (b) the antibody is in solution and the antigen is immobilized of the fibre-optic surface. For example when the antigen is immobilized, an increase in the fractal dimension value (anti-Ars) in solution leads to (a) an increase in the fractal dimension value and hence the state of disorder or roughness, and (b) a higher rate coefficient for binding on the fibre-optic surface. An analysis of the influence of different parameters on the fractal dimension values for a particular effect, such as a comparison of fresh and regenerated immunosensors, helps to clarify the conformational states and reactions occurring on the fibre-optic surface. Examination of the different cases presented together provides novel physical insights into the state of disorder or roughness on the surface. This research should contribute towards techniques for manipulating the reactions occuring on fibre-optic surfaces in desired directions." @default.
- W2003269888 created "2016-06-24" @default.
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- W2003269888 date "1995-01-01" @default.
- W2003269888 modified "2023-09-23" @default.
- W2003269888 title "Antigen-antibody diffusion-limited binding kinetics of biosensors: a fractal analysis" @default.
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- W2003269888 doi "https://doi.org/10.1016/0956-5663(95)96849-t" @default.
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