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• W2003276538 abstract "mRNA and protein analyses have previously shown that the diaphragm expresses two ryanodine receptor isoforms: RyR1 and RyR3.RyR1 is the main Ca 2+ -releasing pathway in this muscle type. We now report the conducting, gating, and immunological properties of the native and purified forms of the less abundant RyR3 channel. The conductance of this native Ca 2+ -release channel was 330 pS in 50 mM/250 mM trans/cis CsCH 3 SO 3 . It was activated by Ca 2+ concentrations of 1-1000 µM, and did not inactivate at mM concentrations of Ca 2+ . Both isoforms were purified by either a sucrose density gradient or immunoprecipitation as > 450 kDa proteins on SDS-PAGE. Western blot analysis confirmed the presence of RyR1 and RyR3, which displayed conductances of 740 ± 30 and 800 ± 25 pS, respectively, in 250 mM KCl. We thus provide evidence that one form of the diaphragm SR Ca 2+ -release channels may be classified as RyR3, with gating properties different from those of the well-characterized RyR1 and RyR2 isoforms.Key words: diaphragm, calcium channel, ryanodine receptors, skeletal muscles, excitation-contraction coupling." @default.
• W2003276538 created "2016-06-24" @default.
• W2003276538 creator A5036775454 @default.
• W2003276538 creator A5088723836 @default.
• W2003276538 date "2001-04-01" @default.
• W2003276538 modified "2023-09-27" @default.
• W2003276538 title "Functional properties of the native type 3 ryanodine receptor Ca2+-release channel from canine diaphragm" @default.
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• W2003276538 doi "https://doi.org/10.1139/y00-127" @default.
• W2003276538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11332508" @default.
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