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• W2003283925 endingPage "954" @default.
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• W2003283925 abstract "Purpose To assess the feasibility of dosimetrically sparing the hippocampus and neural stem cell (NSC) compartment during whole-brain radiotherapy (WBRT) and prophylactic cranial irradiation (PCI). Methods and Materials We contoured the brain/brainstem on fused magnetic resonance /computed tomography images as the planning target volume (PTV) in 10 patients, excluding the hippocampus and NSC compartment as organs at risk. PCI and WBRT helical tomotherapy plans were prepared for each patient, with 1.0-cm field width, a pitch of 0.285, and a modulation factor of 2.5. We attempted to maximally spare the hippocampus and NSC compartment while treating the rest of the brain to 30 Gy in 15 fractions (PCI) or 35 Gy in 14 fractions (WBRT) with a V100 of ≥95%. Plan quality was assessed by calculating mean dose, equivalent uniform dose (EUD), and biologically equivalent dose (BED) for organs at risk and the percent volume of the PTV receiving the prescribed dose of V100. Results In the PCI plans, mean doses/EUD/BED for the hippocampus and NSC compartment were 11.5 Gy/13.1 Gy/15.7 Gy2 (BED assuming alpha/beta ratio of 2Gy) and 11.5 Gy/13.1 Gy/12.3 Gy10 (BED assuming alpha/beta ratio of 10Gy), respectively. In the WBRT plans, mean doses/EUD/BED for the hippocampus and NSC compartment were 11.8 Gy/14.8 Gy/16.8 Gy2 and 11.8 Gy/14.8 Gy/12.8 Gy10, respectively. The mean V95 for the rest of the brain (PTV) was 96.9% for both the PCI and WBRT plans. Mean PCI and WBRT treatment times were 15.93 min (range, 14.28 min–17.50 min) and 20.18 min (range, 18.43 min–22.32 min), respectively. Conclusions It is dosimetrically feasible to spare the hippocampus and NSC compartment using helical tomotherapy during the administration of whole-brain irradiation. To assess the feasibility of dosimetrically sparing the hippocampus and neural stem cell (NSC) compartment during whole-brain radiotherapy (WBRT) and prophylactic cranial irradiation (PCI). We contoured the brain/brainstem on fused magnetic resonance /computed tomography images as the planning target volume (PTV) in 10 patients, excluding the hippocampus and NSC compartment as organs at risk. PCI and WBRT helical tomotherapy plans were prepared for each patient, with 1.0-cm field width, a pitch of 0.285, and a modulation factor of 2.5. We attempted to maximally spare the hippocampus and NSC compartment while treating the rest of the brain to 30 Gy in 15 fractions (PCI) or 35 Gy in 14 fractions (WBRT) with a V100 of ≥95%. Plan quality was assessed by calculating mean dose, equivalent uniform dose (EUD), and biologically equivalent dose (BED) for organs at risk and the percent volume of the PTV receiving the prescribed dose of V100. In the PCI plans, mean doses/EUD/BED for the hippocampus and NSC compartment were 11.5 Gy/13.1 Gy/15.7 Gy2 (BED assuming alpha/beta ratio of 2Gy) and 11.5 Gy/13.1 Gy/12.3 Gy10 (BED assuming alpha/beta ratio of 10Gy), respectively. In the WBRT plans, mean doses/EUD/BED for the hippocampus and NSC compartment were 11.8 Gy/14.8 Gy/16.8 Gy2 and 11.8 Gy/14.8 Gy/12.8 Gy10, respectively. The mean V95 for the rest of the brain (PTV) was 96.9% for both the PCI and WBRT plans. Mean PCI and WBRT treatment times were 15.93 min (range, 14.28 min–17.50 min) and 20.18 min (range, 18.43 min–22.32 min), respectively. It is dosimetrically feasible to spare the hippocampus and NSC compartment using helical tomotherapy during the administration of whole-brain irradiation." @default.
• W2003283925 created "2016-06-24" @default.
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• W2003283925 date "2010-11-01" @default.
• W2003283925 modified "2023-10-17" @default.
• W2003283925 title "Sparing of the Neural Stem Cell Compartment During Whole-Brain Radiation Therapy: A Dosimetric Study Using Helical Tomotherapy" @default.
• W2003283925 cites W1581458838 @default.
• W2003283925 cites W1670625131 @default.
• W2003283925 cites W1859730138 @default.
• W2003283925 cites W1967121735 @default.
• W2003283925 cites W1968421135 @default.
• W2003283925 cites W1971660087 @default.
• W2003283925 cites W1976118071 @default.
• W2003283925 cites W1976996553 @default.
• W2003283925 cites W1977666111 @default.
• W2003283925 cites W1980286364 @default.
• W2003283925 cites W1981143910 @default.
• W2003283925 cites W1981936395 @default.
• W2003283925 cites W1985094241 @default.
• W2003283925 cites W1988135514 @default.
• W2003283925 cites W1990646544 @default.
• W2003283925 cites W1999927211 @default.
• W2003283925 cites W2002514998 @default.
• W2003283925 cites W2003917401 @default.
• W2003283925 cites W2004451956 @default.
• W2003283925 cites W2006326440 @default.
• W2003283925 cites W2008153607 @default.
• W2003283925 cites W2011588898 @default.
• W2003283925 cites W2017830253 @default.
• W2003283925 cites W2018952014 @default.
• W2003283925 cites W2019765299 @default.
• W2003283925 cites W2021648471 @default.
• W2003283925 cites W2022600603 @default.
• W2003283925 cites W2035250926 @default.
• W2003283925 cites W2036760484 @default.
• W2003283925 cites W2037539116 @default.
• W2003283925 cites W2037623144 @default.
• W2003283925 cites W2039094545 @default.
• W2003283925 cites W2039424107 @default.
• W2003283925 cites W2044209244 @default.
• W2003283925 cites W2046575314 @default.
• W2003283925 cites W2049169699 @default.
• W2003283925 cites W2061962226 @default.
• W2003283925 cites W2062938528 @default.
• W2003283925 cites W2063480451 @default.
• W2003283925 cites W2067856703 @default.
• W2003283925 cites W2068298675 @default.
• W2003283925 cites W2070658919 @default.
• W2003283925 cites W2071181288 @default.
• W2003283925 cites W2072832150 @default.
• W2003283925 cites W2079156156 @default.
• W2003283925 cites W2084056177 @default.
• W2003283925 cites W2090734831 @default.
• W2003283925 cites W2098137179 @default.
• W2003283925 cites W2100410313 @default.
• W2003283925 cites W2104165122 @default.
• W2003283925 cites W2109490458 @default.
• W2003283925 cites W2138683149 @default.
• W2003283925 cites W2142525943 @default.
• W2003283925 cites W2148943496 @default.
• W2003283925 cites W2150792841 @default.
• W2003283925 cites W2152794331 @default.
• W2003283925 cites W2158789700 @default.
• W2003283925 cites W2168272960 @default.
• W2003283925 cites W2174482320 @default.
• W2003283925 cites W2339444986 @default.
• W2003283925 doi "https://doi.org/10.1016/j.ijrobp.2009.12.012" @default.
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