Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003284108> ?p ?o ?g. }
- W2003284108 endingPage "1038" @default.
- W2003284108 startingPage "1027" @default.
- W2003284108 abstract "The human Rad52 protein stimulates joint molecule formation by hRad51, a homologue of Escherichia coli RecA protein. Electron microscopic analysis of hRad52 shows that it self-associates to form ring structures with a diameter of approximately 10 nm. Each ring contains a hole at its centre. hRad52 binds to single and double-stranded DNA. In the ssDNA-hRad52 complexes, hRad52 was distributed along the length of the DNA, which exhibited a characteristic beads on a string appearance. At higher concentrations of hRad52, super-rings (approximately 30 nm) were observed and the ssDNA was collapsed upon itself. In contrast, in dsDNA-hRad52 complexes, some regions of the DNA remained protein-free while others, containing hRad52, interacted to form large protein-DNA networks. Saturating concentrations of hRad51 displaced hRad52 from ssDNA, whereas dsDNA-Rad52 complexes (networks) were more resistant to hRad51 invasion and nucleoprotein filament formation. When Rad52-Rad51-DNA complexes were probed with gold-conjugated hRad52 antibodies, the presence of globular hRad52 structures within the Rad51 nucleoprotein filament was observed. These data provide the first direct visualisation of protein-DNA complexes formed by the human Rad51 and Rad52 recombination/repair proteins." @default.
- W2003284108 created "2016-06-24" @default.
- W2003284108 creator A5001116361 @default.
- W2003284108 creator A5009796470 @default.
- W2003284108 creator A5054117046 @default.
- W2003284108 creator A5068671173 @default.
- W2003284108 date "1998-12-01" @default.
- W2003284108 modified "2023-10-13" @default.
- W2003284108 title "Visualisation of human rad52 protein and its complexes with hrad51 and DNA" @default.
- W2003284108 cites W1532653491 @default.
- W2003284108 cites W1539685331 @default.
- W2003284108 cites W1604305208 @default.
- W2003284108 cites W1635460358 @default.
- W2003284108 cites W185329323 @default.
- W2003284108 cites W1913367356 @default.
- W2003284108 cites W1967222453 @default.
- W2003284108 cites W1971887411 @default.
- W2003284108 cites W1979177473 @default.
- W2003284108 cites W1979327836 @default.
- W2003284108 cites W1985373258 @default.
- W2003284108 cites W1987345634 @default.
- W2003284108 cites W1991617089 @default.
- W2003284108 cites W1992101827 @default.
- W2003284108 cites W1992398829 @default.
- W2003284108 cites W2000657327 @default.
- W2003284108 cites W2003755228 @default.
- W2003284108 cites W2011881129 @default.
- W2003284108 cites W2015061812 @default.
- W2003284108 cites W2016208064 @default.
- W2003284108 cites W2021476934 @default.
- W2003284108 cites W2022100127 @default.
- W2003284108 cites W2024116210 @default.
- W2003284108 cites W2028084970 @default.
- W2003284108 cites W2035705087 @default.
- W2003284108 cites W2035994249 @default.
- W2003284108 cites W2036510598 @default.
- W2003284108 cites W2041929141 @default.
- W2003284108 cites W2046082194 @default.
- W2003284108 cites W2052521064 @default.
- W2003284108 cites W2056750443 @default.
- W2003284108 cites W2070810615 @default.
- W2003284108 cites W2073290193 @default.
- W2003284108 cites W2078903669 @default.
- W2003284108 cites W2081581449 @default.
- W2003284108 cites W2086871899 @default.
- W2003284108 cites W2091350790 @default.
- W2003284108 cites W2095248966 @default.
- W2003284108 cites W2113227424 @default.
- W2003284108 cites W2115569175 @default.
- W2003284108 cites W2128370098 @default.
- W2003284108 cites W2140732239 @default.
- W2003284108 cites W2157269460 @default.
- W2003284108 cites W2242861315 @default.
- W2003284108 cites W4249343944 @default.
- W2003284108 cites W4256250819 @default.
- W2003284108 doi "https://doi.org/10.1006/jmbi.1998.2203" @default.
- W2003284108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9837724" @default.
- W2003284108 hasPublicationYear "1998" @default.
- W2003284108 type Work @default.
- W2003284108 sameAs 2003284108 @default.
- W2003284108 citedByCount "103" @default.
- W2003284108 countsByYear W20032841082013 @default.
- W2003284108 countsByYear W20032841082014 @default.
- W2003284108 countsByYear W20032841082015 @default.
- W2003284108 countsByYear W20032841082016 @default.
- W2003284108 countsByYear W20032841082017 @default.
- W2003284108 countsByYear W20032841082018 @default.
- W2003284108 countsByYear W20032841082019 @default.
- W2003284108 countsByYear W20032841082020 @default.
- W2003284108 countsByYear W20032841082021 @default.
- W2003284108 countsByYear W20032841082022 @default.
- W2003284108 countsByYear W20032841082023 @default.
- W2003284108 crossrefType "journal-article" @default.
- W2003284108 hasAuthorship W2003284108A5001116361 @default.
- W2003284108 hasAuthorship W2003284108A5009796470 @default.
- W2003284108 hasAuthorship W2003284108A5054117046 @default.
- W2003284108 hasAuthorship W2003284108A5068671173 @default.
- W2003284108 hasConcept C104317684 @default.
- W2003284108 hasConcept C113271649 @default.
- W2003284108 hasConcept C12554922 @default.
- W2003284108 hasConcept C134935766 @default.
- W2003284108 hasConcept C14228908 @default.
- W2003284108 hasConcept C153911025 @default.
- W2003284108 hasConcept C185592680 @default.
- W2003284108 hasConcept C2776630724 @default.
- W2003284108 hasConcept C2779012473 @default.
- W2003284108 hasConcept C5179208 @default.
- W2003284108 hasConcept C552990157 @default.
- W2003284108 hasConcept C55493867 @default.
- W2003284108 hasConcept C60325843 @default.
- W2003284108 hasConcept C86339819 @default.
- W2003284108 hasConcept C86803240 @default.
- W2003284108 hasConcept C94966510 @default.
- W2003284108 hasConceptScore W2003284108C104317684 @default.
- W2003284108 hasConceptScore W2003284108C113271649 @default.
- W2003284108 hasConceptScore W2003284108C12554922 @default.
- W2003284108 hasConceptScore W2003284108C134935766 @default.
- W2003284108 hasConceptScore W2003284108C14228908 @default.