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• W2003286952 abstract "The generation of the photosensitizer protoporphyrin IX (PpIX) in cells can be induced by externally applied 5-aminolevulinic acid (ALA), with that bypassing the feedback control mechanism. The aim of the present study was to investigate the onset of destructive changes in living cocultivated WI38 and VA13-transformed WI38 human fibroblasts following ALA incubation, PpIX production and subsequent irradiation by white halogen light with a dose of 2.2 kJ/m2. Specific fluorescence markers such as 3,3'-dihexyloxacarbocyanine iodide for endoplasmic reticulum (ER) staining and dihydrorhodamine for intact mitochondria mapping combined with a low light imaging system are a versatile and sensitive tool to examine the photoinduced destruction of organelles in living cells, while artifacts are minimized. Mitochondria as primary targets of PpIX undergo a condensation under irradiation and are finally destroyed. Photodynamic treatment induces further a significant decomposition of ER, although PpIX localization could not be determined. Initial destabilization and vesiculation of ER is followed by a porous network with large cisternae (indicating the breakdown of cell integrity and cell/nucleus membrane damage). Normal cocultivated lung fibroblasts showed a delay in destruction compared to the transformed WI38-VA13 cells. The observed decomposition pattern resembles the morphological pattern of apoptosis." @default.
• W2003286952 created "2016-06-24" @default.
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• W2003286952 date "2008-01-02" @default.
• W2003286952 modified "2023-09-25" @default.
• W2003286952 title "SUBCELLULAR DAMAGE KINETICS WITHIN CO-CULTIVATED WI38 and VA13-TRANSFORMED WI38 HUMAN FIBROBLASTS FOLLOWING 5-AMINOLEVULINIC ACID-INDUCED PROTOPORPHYRIN IX FORMATION" @default.
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• W2003286952 doi "https://doi.org/10.1111/j.1751-1097.1995.tb02408.x" @default.
• W2003286952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8570739" @default.
• W2003286952 hasPublicationYear "2008" @default.
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