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• W2003289462 startingPage "121" @default.
• W2003289462 abstract "Drug abuse researchers have noted striking similarities between behaviors elicited by Pavlovian sign-tracking procedures and prominent symptoms of drug abuse. In Pavlovian sign-tracking procedures, repeated paired presentations of a small object (conditioned stimulus, CS) with a reward (unconditioned stimulus, US) elicits a conditioned response (CR) that typically consists of approaching the CS, contacting the CS, and expressing consummatory responses at the CS. Sign-tracking CR performance is poorly controlled and exhibits spontaneous recovery and long-term retention, effects that resemble relapse. Sign-tracking resembles psychomotor activation, a syndrome of behavioral responses evoked by addictive drugs, and the effects of sign-tracking on corticosterone levels and activation of dopamine pathways resemble the neurobiological effects of abused drugs. Finally, the neurobiological profile of individuals susceptible to sign-tracking resembles the pathophysiological profile of vulnerability to drug abuse, and vulnerability to sign-tracking predicts vulnerability to impulsive responding and alcohol self-administration. Implications of sign-tracking for models of drug addiction are considered." @default.
• W2003289462 created "2016-06-24" @default.
• W2003289462 creator A5045520530 @default.
• W2003289462 creator A5058272614 @default.
• W2003289462 creator A5082423437 @default.
• W2003289462 date "2008-06-01" @default.
• W2003289462 modified "2023-10-02" @default.
• W2003289462 title "Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse" @default.
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