FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003289983> ?p ?o ?g. }

• W2003289983 endingPage "e91805" @default.
• W2003289983 startingPage "e91805" @default.
• W2003289983 abstract "Cancer is a heterogeneous and tissue-specific disease. Thus, the tissue of origin reflects on the natural history of the disease and dictates the therapeutic approach. It is suggested that tissue differentiation, mediated mostly by epigenetic modifications, could guide tissue-specific susceptibility and protective mechanisms against cancer. Here we studied breast specific methylation in purified normal epithelium and its reflection in breast cancers. We established genome wide methylation profiles of various normal epithelial tissues and identified 110 genes that were differentially methylated in normal breast epithelium. A number of these genes also showed methylation alterations in breast cancers. We elaborated on one of them, TRIM29 (ATDC), and showed that its promoter was hypo-methylated in normal breast epithelium and heavily methylated in other normal epithelial tissues. Moreover, in breast carcinomas methylation increased and expression decreased whereas the reverse was noted for multiple other carcinomas. Interestingly, TRIM29 regulation in breast tumors clustered according to the PAM50 classification. Thus, it was repressed in the estrogen receptor positive tumors, particularly in the more proliferative luminal B subtype. This goes in line with previous reports indicating tumor suppressive activity of TRIM29 in estrogen receptor positive luminal breast cells in contrast to oncogenic function in pancreatic and lung cancers. Overall, these findings emphasize the linkage between breast specific epigenetic regulation and tissue specificity of cancer." @default.
• W2003289983 created "2016-06-24" @default.
• W2003289983 creator A5015567752 @default.
• W2003289983 creator A5021208681 @default.
• W2003289983 creator A5024921034 @default.
• W2003289983 creator A5035271068 @default.
• W2003289983 creator A5036766706 @default.
• W2003289983 creator A5037885355 @default.
• W2003289983 creator A5048240402 @default.
• W2003289983 creator A5052396098 @default.
• W2003289983 creator A5064788292 @default.
• W2003289983 creator A5066728112 @default.
• W2003289983 creator A5073971357 @default.
• W2003289983 creator A5081735518 @default.
• W2003289983 date "2014-03-20" @default.
• W2003289983 modified "2023-09-27" @default.
• W2003289983 title "Tissue Specific DNA Methylation in Normal Human Breast Epithelium and in Breast Cancer" @default.
• W2003289983 cites W1601826601 @default.
• W2003289983 cites W1967530830 @default.
• W2003289983 cites W1975134052 @default.
• W2003289983 cites W1980937575 @default.
• W2003289983 cites W1991131199 @default.
• W2003289983 cites W2020541351 @default.
• W2003289983 cites W2021459974 @default.
• W2003289983 cites W2032891689 @default.
• W2003289983 cites W2040318436 @default.
• W2003289983 cites W2043404158 @default.
• W2003289983 cites W2044822742 @default.
• W2003289983 cites W2055327776 @default.
• W2003289983 cites W2088947549 @default.
• W2003289983 cites W2092618961 @default.
• W2003289983 cites W2097255042 @default.
• W2003289983 cites W2117692326 @default.
• W2003289983 cites W2125154191 @default.
• W2003289983 cites W2127613358 @default.
• W2003289983 cites W2131994307 @default.
• W2003289983 cites W2132619562 @default.
• W2003289983 cites W2134079044 @default.
• W2003289983 cites W2134721845 @default.
• W2003289983 cites W2139780561 @default.
• W2003289983 cites W2140978190 @default.
• W2003289983 cites W2141305489 @default.
• W2003289983 cites W2148521032 @default.
• W2003289983 cites W2158217645 @default.
• W2003289983 cites W2161250377 @default.
• W2003289983 cites W2166082118 @default.
• W2003289983 cites W2916022153 @default.
• W2003289983 cites W4230096730 @default.
• W2003289983 doi "https://doi.org/10.1371/journal.pone.0091805" @default.
• W2003289983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3961270" @default.
• W2003289983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24651077" @default.
• W2003289983 hasPublicationYear "2014" @default.
• W2003289983 type Work @default.
• W2003289983 sameAs 2003289983 @default.
• W2003289983 citedByCount "23" @default.
• W2003289983 countsByYear W20032899832015 @default.
• W2003289983 countsByYear W20032899832016 @default.
• W2003289983 countsByYear W20032899832017 @default.
• W2003289983 countsByYear W20032899832018 @default.
• W2003289983 countsByYear W20032899832019 @default.
• W2003289983 countsByYear W20032899832020 @default.
• W2003289983 countsByYear W20032899832021 @default.
• W2003289983 countsByYear W20032899832022 @default.
• W2003289983 crossrefType "journal-article" @default.
• W2003289983 hasAuthorship W2003289983A5015567752 @default.
• W2003289983 hasAuthorship W2003289983A5021208681 @default.
• W2003289983 hasAuthorship W2003289983A5024921034 @default.
• W2003289983 hasAuthorship W2003289983A5035271068 @default.
• W2003289983 hasAuthorship W2003289983A5036766706 @default.
• W2003289983 hasAuthorship W2003289983A5037885355 @default.
• W2003289983 hasAuthorship W2003289983A5048240402 @default.
• W2003289983 hasAuthorship W2003289983A5052396098 @default.
• W2003289983 hasAuthorship W2003289983A5064788292 @default.
• W2003289983 hasAuthorship W2003289983A5066728112 @default.
• W2003289983 hasAuthorship W2003289983A5073971357 @default.
• W2003289983 hasAuthorship W2003289983A5081735518 @default.
• W2003289983 hasBestOaLocation W20032899831 @default.
• W2003289983 hasConcept C104317684 @default.
• W2003289983 hasConcept C111683008 @default.
• W2003289983 hasConcept C118646709 @default.
• W2003289983 hasConcept C121608353 @default.
• W2003289983 hasConcept C142724271 @default.
• W2003289983 hasConcept C150194340 @default.
• W2003289983 hasConcept C190727270 @default.
• W2003289983 hasConcept C33288867 @default.
• W2003289983 hasConcept C41091548 @default.
• W2003289983 hasConcept C502942594 @default.
• W2003289983 hasConcept C529295009 @default.
• W2003289983 hasConcept C530470458 @default.
• W2003289983 hasConcept C54355233 @default.
• W2003289983 hasConcept C71924100 @default.
• W2003289983 hasConcept C84606932 @default.
• W2003289983 hasConcept C86803240 @default.
• W2003289983 hasConceptScore W2003289983C104317684 @default.
• W2003289983 hasConceptScore W2003289983C111683008 @default.
• W2003289983 hasConceptScore W2003289983C118646709 @default.
• W2003289983 hasConceptScore W2003289983C121608353 @default.
• W2003289983 hasConceptScore W2003289983C142724271 @default.

• next