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- W2003292110 abstract "Degradation of heme requires its conversion to biliverdin (BV) by heme oxygenase, followed by reduction of BV to the free-radical quencher bilirubin (BR) by biliverdin reductase (BVR). It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser/Thr and Tyr) upstream activator of the insulin/insulin growth factor-1 (IGF-1) and mitogen-activated protein kinase (MAPK) signaling pathways. hBVR is also a basic-leucine-zipper (bZip) DNA/chromatin-binding transcription factor, an activator and anchor protein for translocation of protein kinase C betaII and zeta isozymes within cell compartments, and a kinase kinase for their activation. hBVR is essential for MAPK-extracellular signal-regulated kinase (ERK)1/2 (MEK)-eukaryotic-like protein kinase (Elk) signaling and has been identified as the cytoplasm-nuclear heme transporter of ERK1/2 and hematin, the key components of stress-responsive gene expression. Here, we discuss the recently uncovered functions of hBVR in cell signaling and regulation of gene expression, and the role of BR in cellular signaling, cytoprotection and cytotoxicity." @default.
- W2003292110 created "2016-06-24" @default.
- W2003292110 creator A5001051903 @default.
- W2003292110 creator A5009202781 @default.
- W2003292110 date "2009-03-01" @default.
- W2003292110 modified "2023-09-23" @default.
- W2003292110 title "Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin" @default.
- W2003292110 cites W1164935966 @default.
- W2003292110 cites W1497013369 @default.
- W2003292110 cites W1576671418 @default.
- W2003292110 cites W1580054285 @default.
- W2003292110 cites W1757381995 @default.
- W2003292110 cites W1924592317 @default.
- W2003292110 cites W1966582616 @default.
- W2003292110 cites W1968791438 @default.
- W2003292110 cites W1972172786 @default.
- W2003292110 cites W1975042178 @default.
- W2003292110 cites W1975124499 @default.
- W2003292110 cites W1979560937 @default.
- W2003292110 cites W1983339726 @default.
- W2003292110 cites W1987777210 @default.
- W2003292110 cites W1988130146 @default.
- W2003292110 cites W1990794882 @default.
- W2003292110 cites W1991420366 @default.
- W2003292110 cites W1992879610 @default.
- W2003292110 cites W1994461285 @default.
- W2003292110 cites W1996227024 @default.
- W2003292110 cites W1999554896 @default.
- W2003292110 cites W2005904261 @default.
- W2003292110 cites W2006738521 @default.
- W2003292110 cites W2007789422 @default.
- W2003292110 cites W2021186614 @default.
- W2003292110 cites W2023505847 @default.
- W2003292110 cites W2032334145 @default.
- W2003292110 cites W2039445636 @default.
- W2003292110 cites W2047761952 @default.
- W2003292110 cites W2048646132 @default.
- W2003292110 cites W2049039129 @default.
- W2003292110 cites W2051315704 @default.
- W2003292110 cites W2054324086 @default.
- W2003292110 cites W2054724205 @default.
- W2003292110 cites W2056357865 @default.
- W2003292110 cites W2064569489 @default.
- W2003292110 cites W2069711307 @default.
- W2003292110 cites W2074204454 @default.
- W2003292110 cites W2077748031 @default.
- W2003292110 cites W2078609739 @default.
- W2003292110 cites W2087720482 @default.
- W2003292110 cites W2093057466 @default.
- W2003292110 cites W2095002839 @default.
- W2003292110 cites W2097499819 @default.
- W2003292110 cites W2099244520 @default.
- W2003292110 cites W2102685783 @default.
- W2003292110 cites W2103783218 @default.
- W2003292110 cites W2105729793 @default.
- W2003292110 cites W2109479348 @default.
- W2003292110 cites W2110303041 @default.
- W2003292110 cites W2113780363 @default.
- W2003292110 cites W2117029515 @default.
- W2003292110 cites W2119855284 @default.
- W2003292110 cites W2123431152 @default.
- W2003292110 cites W2124163811 @default.
- W2003292110 cites W2127652299 @default.
- W2003292110 cites W2127798432 @default.
- W2003292110 cites W2128501867 @default.
- W2003292110 cites W2129535784 @default.
- W2003292110 cites W2137890268 @default.
- W2003292110 cites W2138625851 @default.
- W2003292110 cites W2140889728 @default.
- W2003292110 cites W2148205722 @default.
- W2003292110 cites W2152907187 @default.
- W2003292110 cites W2153697892 @default.
- W2003292110 cites W2160332942 @default.
- W2003292110 cites W2161414034 @default.
- W2003292110 cites W2167573033 @default.
- W2003292110 cites W2169161738 @default.
- W2003292110 cites W2171885946 @default.
- W2003292110 cites W2418194756 @default.
- W2003292110 cites W3102875255 @default.
- W2003292110 cites W2077823344 @default.
- W2003292110 doi "https://doi.org/10.1016/j.tips.2008.12.003" @default.
- W2003292110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19217170" @default.
- W2003292110 hasPublicationYear "2009" @default.
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