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- W2003294342 abstract "The objective of this study was to determine the proportion of patients with atherosclerotic peripheral vascular disease (PVD) who had elevated lipoprotein(a) [Lp(a)] levels, as well as to determine the latter's significance as a risk factor for PVD in the local population.This case-controlled study was conducted between June and October 2004 in the Department of Surgery, Kuala Lumpur Hospital. A total of 100 patients were recruited and divided into control and PVD groups. Patients were defined as having PVD if they were symptomatic, with ankle-brachial systolic index < 0.90, or by radiological evidence. Lp(a) concentrations were determined using immunoturbidometry. Absorbance of reaction precipitate was measured by spectrophotometry to give Lp(a) concentration in grams per litre (g/L). The reference value for normal Lp(a) levels was < or = 0.36 g/L.Mean Lp(a) levels for control and PVD groups were 0.29 g/L and 0.56 g/L, and median values were 0.17 g/L and 0.48 g/L, respectively. Elevated Lp(a) levels in the control group was 26% compared to 58% in the PVD group. Analysis with Pearson's chi-squared test achieved a significant p value of 0.001. Multivariate analysis showed that elevated Lp(a) levels contributed significantly to the probability of having PVD with an odds ratio of 7.69.Elevated serum Lp(a) has a significant role as a risk factor for atherosclerotic PVD in the local population." @default.
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- W2003294342 date "2008-01-01" @default.
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- W2003294342 title "Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur" @default.
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- W2003294342 doi "https://doi.org/10.1016/s1015-9584(08)60048-2" @default.
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