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- W2003295975 abstract "Maternal infection or inflammation may induce fetal inflammatory responses associated with fetal injury and cerebral palsy. We sought to assess the inflammation-associated neuroprotective potential of prophylactic NAC, a known anti-inflammatory agent. We examined the effect of NAC on prevention of maternal lipopolysaccharide (LPS) - induced neonatal brain injury using MRI. Pregnant Sprague Dawley dams at d18 (n=5) received i.p. injection of LPS (500 μg/kg, i.p.) or saline at time 0. Animals were randomized to receive two IV injections (tail vein) of NAC (300 mg/kg) or saline (time -30 and 120 min). Pups were delivered spontaneously (e21) and allowed to mature until postnatal day 25. Female offspring (5-8 per group) were examined under isoflurane anesthesia by MRI brain imaging and analyzed using voxel based analysis (VBA) after spatial normalization. T2 relaxation time was used to assess white matter injury and diffusion tensor imaging for Apparent Diffusion Coefficient (ADC) to assess white and gray matter injury. Offspring of LPS-treated dams exhibited (1) significantly increased T2 levels, and (2) increased ADC levels (increased by 10% ) in white and gray matter (eg, hypothalamus, motor cortex ,corpus callosum, thalamus, hippocampus), consistent with diffuse cerebral injury. In contrast, offspring of NAC-treated LPS dams demonstrated similar T2 and ADC levels as Control in both white and gray matter. There was a trend towards more newborn pups in the LPS-NAC group compared to the LPS group (12.2 vs 8.2 pups, p=0.08) Maternal NAC treatment significantly reduced evidence of neonatal brain injury associated with maternal LPS. These studies suggest that maternal NAC therapy may be effective in human preterm deliveries associated with maternal/fetal inflammation." @default.
- W2003295975 created "2016-06-24" @default.
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- W2003295975 date "2013-01-01" @default.
- W2003295975 modified "2023-10-05" @default.
- W2003295975 title "76: Prophylactic maternal N-acetyl-cysteine (NAC) prevents maternal inflammation-induced offspring cerebral injury evident by magnetic resonance imaging (MRI)" @default.
- W2003295975 doi "https://doi.org/10.1016/j.ajog.2012.10.241" @default.
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