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- W2003297107 abstract "Abstract: The effects of H1-blockers (pyrilamine, diphenhydramine and promethazine) and H2-blockers (cimetidine, ranitidine) on the postsynaptic potentials of the bull-frog sympathetic ganglion were studied by means of the sucrose gap method. All the H1-blockers tested, at concentrations of 10−6-10−4 M, depressed the amplitudes of both action and slow postsynaptic potentials in positive and negative directions in a concentration-dependent manner; these drugs had more potent inhibitory effects on postsynaptic potentials. In the case of H2-blockers, action and postsynaptic potentials were slightly depressed as perfusion continued at 10−4 M. From the present experiments, it was concluded that H1-blockers directly inhibit postsynaptic potentials of the sympathetic ganglions, and that this inhibition may be responsible for various autonomic disturbances attributed to H1-blockers." @default.
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- W2003297107 date "1988-09-01" @default.
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- W2003297107 title "The Effects of H1- and H2-Receptor Blocking Agents on Postsynaptic Potentials Recorded from the Bull-frog Sympathetic Ganglion" @default.
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- W2003297107 doi "https://doi.org/10.1111/j.1600-0773.1988.tb00931.x" @default.
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