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• W2003299672 abstract "Mice were infected with the intracellular bacterium, Listeria monocytogenes, and T cell clones from spleens, lymph nodes and peritoneal exudates were established. The capacity of L3T4+, Lyt2− T-cell clones to specifically lyse L. monocytogenes-infected macrophages was analyzed. As a source of target cells, bone marrow macrophages (BMMΦ) after 9 days of culture in hydrophobic teflon bags were used. These BMMΦ were totally Ia−; however, significant Ia-expression could be induced by interferon-γ (IFN-γ). IFN-γ-stimulated BMMΦ, after priming with live or killed L. monocytogenes organisms were effectively lysed by the vast majority of L3T4+ T cell clones. In the absence of either IFN-γ stimulation or antigen priming, no lysis occurred. Cytolysis was demonstrable in a conventional 4-h 51Cr-release assay and in an 18-h neutral red uptake assay and was antigen specific and class II restricted. Native T cells from L. monocytogenes-infected mice failed to lyse stimulated, L. monocytogenes-primed BMMΦ and gained their cytolytic activity after antigenic restimulation in vitro. These data demonstrate that L. monocytogenes-specific L3T4+ T cells could lyse MΦ presenting listerial antigens provided that Ia antigen expression had been induced. L3T4+ T cell clones produced IFN-γ after restimulation with antigen plus accessory cells in vitro and IFN-γ secretion could be increased by costimulation with recombinant IL 2. These T cell clones conferred significant protection upon recipient mice which was more pronounced in the liver. The possible relevance of lysis by L3T4+ T cells of infected MΦ to protection against and pathogenesis of intracellular bacterial infections is discussed." @default.
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• W2003299672 date "1987-01-01" @default.
• W2003299672 modified "2023-10-17" @default.
• W2003299672 title "Specific lysis ofListeria monocytogenes-infected macrophages by class II-restricted L3T4+ T cells" @default.
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• W2003299672 doi "https://doi.org/10.1002/eji.1830170214" @default.
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