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- W2003300110 abstract "Summary ‘Dipasic’ is a substance consisting of an equimolecular chemical combination between PAS and isoniazid. It has been claimed to possess an antituberculous action independent of its PAS and isoniazid content. Eleven patients with far-advanced, grossly cavitated disease were treated with ‘dipasic’. Tubercle bacilli from all 11 were resistant to isoniazid and from 10 to PAS also. Progress was followed by careful quantitative bacteriological examination and by ‘population studies’ as well as by objective clinical means. It was not possible to detect any effect attributable to ‘dipasic’. We have, therefore, found no evidence that ‘dipasic’ acts as a compound independent of its isoniazid and PAS content. Tubercle bacilli resistant to isoniazid, but sensitive to PAS, may appear to be sensitive to ‘dipasic’ by virtue of its small PAS content. Because of the small quantity of PAS present no clinical effect is to be expected in patients with isoniazid resistant bacilli; and none was obtained in the one such case reported here. Biological assay of serum ‘dipasic’ levels confirms the very low level of activity attributable to the PAS fraction of ‘dipasic’. In a survey of the available literature we have found no good evidence for the claim that the use of ‘dipasic’ delays or prevents the emergence of isoniazid resistant bacilli. The scanty evidence suggests that even if it has such an action, ‘dipasic’ is less effective in this respect than isoniazid plus PAS in customary doses. For practical purposes treatment with ‘dipasic’ should be regarded as equivalent to treatment with isoniazid alone." @default.
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- W2003300110 date "1957-01-01" @default.
- W2003300110 modified "2023-09-27" @default.
- W2003300110 title "The treatment of pulmonary tuberculosis with ‘Dipasic’" @default.
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- W2003300110 doi "https://doi.org/10.1016/s0041-3879(57)80179-2" @default.
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