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- W2003303368 abstract "Better understanding of the cellular and molecular mechanisms of asthma have made it possible to envision a large number of new treatment targets. Clinical trials assessing some of these targets were recently published. The results of these trials were often disappointing. For example, parenteral administration of anti-interleukin-5 antibodies diminished bronchial eosinophilic inflammation but without improving either asthma symptoms or bronchial hyperreactivity. Other treatments are promising but have not yet been proved effective in patients with asthma: open studies with anti-TNF alpha antibodies are interesting but the efficacy of this treatment strategy remains uncertain and must be validated against placebo. The first targeted treatment approved for severe difficult-to-control allergic asthma is an anti-IgE monoclonal antibody (omalizumab)." @default.
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- W2003303368 date "2008-01-01" @default.
- W2003303368 modified "2023-10-18" @default.
- W2003303368 title "Thérapeutiques immunologiques ciblées dans l’asthme sévère" @default.
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- W2003303368 doi "https://doi.org/10.1016/j.lpm.2007.08.008" @default.
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