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- W2003304435 endingPage "149" @default.
- W2003304435 startingPage "107" @default.
- W2003304435 abstract "The aliphatic polyamines, putrescine, spermidine and spermine, are normal cell constituents that play important roles in cell proliferation and differentiation. The equilibrium between cellular uptake and release and the balanced activities of biosynthetic and catabolic enzymes of polyamines are essential for normal homeostasis in the proliferation and functions of cells and tissues. However, the intracellular polyamine content increases in hyperplastic or neoplastic growth. Although the involvement of polyamines in physiological and pathological cell proliferation and differentiation has been well established, the role they play is quite different in relation to cell systems and animal models and is dependent on inducer agents and stimuli. Also, the experimental procedures used to deplete polyamines have been shown to influence the cell responses. In this paper, the assay methods currently in use for polyamines are reviewed and compared with respect to sensitivity, reproducibility and applicability to routine analysis. The relevance of polyamine metabolism and the uptake/release process in many physiological and pathological processes is highlighted, and the cellular polyamine pathways are discussed in relation to the possible diagnostic and therapeutic significance of these mediators." @default.
- W2003304435 created "2016-06-24" @default.
- W2003304435 creator A5012265318 @default.
- W2003304435 creator A5014790598 @default.
- W2003304435 creator A5034175821 @default.
- W2003304435 date "2002-12-01" @default.
- W2003304435 modified "2023-10-16" @default.
- W2003304435 title "Analysis of polyamines as markers of (patho)physiological conditions" @default.
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