FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003306295> ?p ?o ?g. }

• W2003306295 endingPage "e106621" @default.
• W2003306295 startingPage "e106621" @default.
• W2003306295 abstract "Blood filtration in the kidney glomerulus is essential for physiological homeostasis. The filtration apparatus of the kidney glomerulus is composed of three distinct components: the fenestrated endothelial cells, the glomerular basement membrane, and interdigitating foot processes of podocytes that form the slit diaphragm. Recent studies have demonstrated that podocytes play a crucial role in blood filtration and in the pathogenesis of proteinuria and glomerular sclerosis; however, the molecular mechanisms that organize the podocyte filtration barrier are not fully understood. In this study, we suggest that tight junction protein 1 (Tjp1 or ZO-1), which is encoded by Tjp1 gene, plays an essential role in establishing the podocyte filtration barrier. The podocyte-specific deletion of Tjp1 down-regulated the expression of podocyte membrane proteins, impaired the interdigitation of the foot processes and the formation of the slit diaphragm, resulting in glomerular dysfunction. We found the possibility that podocyte filtration barrier requires the integration of two independent units, the pre-existing epithelial junction components and the newly synthesized podocyte-specific components, at the final stage in glomerular morphogenesis, for which Tjp1 is indispensable. Together with previous findings that Tjp1 expression was decreased in glomerular diseases in human and animal models, our results indicate that the suppression of Tjp1 could directly aggravate glomerular disorders, highlights Tjp1 as a potential therapeutic target." @default.
• W2003306295 created "2016-06-24" @default.
• W2003306295 creator A5034452500 @default.
• W2003306295 creator A5039231233 @default.
• W2003306295 creator A5039896704 @default.
• W2003306295 creator A5054329378 @default.
• W2003306295 creator A5069175382 @default.
• W2003306295 creator A5072400997 @default.
• W2003306295 creator A5080308473 @default.
• W2003306295 date "2014-09-03" @default.
• W2003306295 modified "2023-10-16" @default.
• W2003306295 title "The Structural and Functional Organization of the Podocyte Filtration Slits Is Regulated by Tjp1/ZO-1" @default.
• W2003306295 cites W1554042779 @default.
• W2003306295 cites W1968216888 @default.
• W2003306295 cites W1974229450 @default.
• W2003306295 cites W1975304753 @default.
• W2003306295 cites W2031098987 @default.
• W2003306295 cites W2031800834 @default.
• W2003306295 cites W2036094375 @default.
• W2003306295 cites W2036094765 @default.
• W2003306295 cites W2046540619 @default.
• W2003306295 cites W2053357822 @default.
• W2003306295 cites W2054225562 @default.
• W2003306295 cites W2069000231 @default.
• W2003306295 cites W2069684013 @default.
• W2003306295 cites W2089067056 @default.
• W2003306295 cites W2095759316 @default.
• W2003306295 cites W2098520903 @default.
• W2003306295 cites W2101140701 @default.
• W2003306295 cites W2103777275 @default.
• W2003306295 cites W2106132002 @default.
• W2003306295 cites W2109578526 @default.
• W2003306295 cites W2110230080 @default.
• W2003306295 cites W2124565234 @default.
• W2003306295 cites W2128545033 @default.
• W2003306295 cites W2129416468 @default.
• W2003306295 cites W2130552692 @default.
• W2003306295 cites W2134123153 @default.
• W2003306295 cites W2143134436 @default.
• W2003306295 cites W2146696453 @default.
• W2003306295 cites W2147249280 @default.
• W2003306295 cites W2153534186 @default.
• W2003306295 cites W2153868488 @default.
• W2003306295 cites W2163543028 @default.
• W2003306295 cites W2167841885 @default.
• W2003306295 cites W2168287443 @default.
• W2003306295 cites W4249900324 @default.
• W2003306295 cites W4253484688 @default.
• W2003306295 cites W4296816736 @default.
• W2003306295 doi "https://doi.org/10.1371/journal.pone.0106621" @default.
• W2003306295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4153657" @default.
• W2003306295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25184792" @default.
• W2003306295 hasPublicationYear "2014" @default.
• W2003306295 type Work @default.
• W2003306295 sameAs 2003306295 @default.
• W2003306295 citedByCount "48" @default.
• W2003306295 countsByYear W20033062952015 @default.
• W2003306295 countsByYear W20033062952016 @default.
• W2003306295 countsByYear W20033062952017 @default.
• W2003306295 countsByYear W20033062952018 @default.
• W2003306295 countsByYear W20033062952019 @default.
• W2003306295 countsByYear W20033062952020 @default.
• W2003306295 countsByYear W20033062952021 @default.
• W2003306295 countsByYear W20033062952022 @default.
• W2003306295 countsByYear W20033062952023 @default.
• W2003306295 crossrefType "journal-article" @default.
• W2003306295 hasAuthorship W2003306295A5034452500 @default.
• W2003306295 hasAuthorship W2003306295A5039231233 @default.
• W2003306295 hasAuthorship W2003306295A5039896704 @default.
• W2003306295 hasAuthorship W2003306295A5054329378 @default.
• W2003306295 hasAuthorship W2003306295A5069175382 @default.
• W2003306295 hasAuthorship W2003306295A5072400997 @default.
• W2003306295 hasAuthorship W2003306295A5080308473 @default.
• W2003306295 hasBestOaLocation W20033062951 @default.
• W2003306295 hasConcept C134018914 @default.
• W2003306295 hasConcept C177779419 @default.
• W2003306295 hasConcept C2776115139 @default.
• W2003306295 hasConcept C2776193487 @default.
• W2003306295 hasConcept C2777146197 @default.
• W2003306295 hasConcept C2778305430 @default.
• W2003306295 hasConcept C2779561371 @default.
• W2003306295 hasConcept C2780091579 @default.
• W2003306295 hasConcept C2780368995 @default.
• W2003306295 hasConcept C2910856063 @default.
• W2003306295 hasConcept C3018201436 @default.
• W2003306295 hasConcept C51872919 @default.
• W2003306295 hasConcept C86803240 @default.
• W2003306295 hasConcept C95444343 @default.
• W2003306295 hasConceptScore W2003306295C134018914 @default.
• W2003306295 hasConceptScore W2003306295C177779419 @default.
• W2003306295 hasConceptScore W2003306295C2776115139 @default.
• W2003306295 hasConceptScore W2003306295C2776193487 @default.
• W2003306295 hasConceptScore W2003306295C2777146197 @default.
• W2003306295 hasConceptScore W2003306295C2778305430 @default.
• W2003306295 hasConceptScore W2003306295C2779561371 @default.
• W2003306295 hasConceptScore W2003306295C2780091579 @default.
• W2003306295 hasConceptScore W2003306295C2780368995 @default.
• W2003306295 hasConceptScore W2003306295C2910856063 @default.

• next