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• W2003307217 endingPage "149" @default.
• W2003307217 startingPage "140" @default.
• W2003307217 abstract "Vascular patterning involves sprouting of blood vessels, which is governed by orchestrated communication between cells in the surrounding tissue and endothelial cells (ECs) lining the blood vessels. Single ECs are selected for sprouting by hypoxia-induced stimuli and become the ‘tip’ or leader cell that guides new sprouts. The ‘stalk’ or trailing ECs proliferate for tube extension and lumenize the nascent vessel. Stalk and tip cells can dynamically switch their identities during this process in a Notch-dependent manner. Here, we review recent studies showing that bone morphogenetic protein (BMP) signaling coregulates Notch target genes in ECs. In particular, we focus on how Delta-like ligand 4 (DLL4)–Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip–stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs. Deeper knowledge about the coregulation of vessel plasticity in different vascular beds may result in refinement of anti-angiogenesis and vessel normalization therapies. Vascular patterning involves sprouting of blood vessels, which is governed by orchestrated communication between cells in the surrounding tissue and endothelial cells (ECs) lining the blood vessels. Single ECs are selected for sprouting by hypoxia-induced stimuli and become the ‘tip’ or leader cell that guides new sprouts. The ‘stalk’ or trailing ECs proliferate for tube extension and lumenize the nascent vessel. Stalk and tip cells can dynamically switch their identities during this process in a Notch-dependent manner. Here, we review recent studies showing that bone morphogenetic protein (BMP) signaling coregulates Notch target genes in ECs. In particular, we focus on how Delta-like ligand 4 (DLL4)–Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip–stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs. Deeper knowledge about the coregulation of vessel plasticity in different vascular beds may result in refinement of anti-angiogenesis and vessel normalization therapies. BMP and DLL4-Notch signaling crosstalk drives oscillatory gene expression in endothelium. Nonsynchronized oscillation networks of BMP-SMAD and Notch effectors dynamically affect EC competences. The HES/HEY molecular oscillators critically depend on ID-mediated BMP-SMAD signaling in ECs. Tip-stalk cell competence and nonsprouting are all balanced by nonsynchronized oscillators. the formation of new blood vessels from pre-existing vessels by vessel sprouting (sprouting angiogenesis) or splitting (intussusception). cells that line the interior surface of blood and lymphatic vessels. an event in which a cell adopts a particular phenotype and prevents its immediate neighbor from acquiring the same phenotype through Notch-mediated signaling. a signaling factor that elicits different cellular responses in responding cells depending on its concentration. During early development, morphogen gradients generate different cell types in a distinct spatial order and pattern in embryos and/or tissues. cells covering the endothelial cell tube. Mural cells stabilize nascent vessels, provide support, and guide remodeling. Pericytes are the mural cells in the microvasculature, whereas vascular smooth muscle cells cover larger vessels. occurs when cells in a tissue exhibit oscillatory gene expression (e.g., HES1 or ID), but the individual cells are in different phases of their cycle. These nonsynchronous oscillations permit differential cellular responses and behavior in a population of cells that is exposed to the same stimulus. quiescent EC. segmental axial structures in the embryo that give rise to the vertebral column, ribs, skeletal muscles, and dermis. the ECs that trail behind the tip cell. These follower cells proliferate, extend the sprout, and form the lumen in nascent vessels. this leader EC extends filopodia and is migratory and polarized. The tip cell pulls the stalk cells into the emerging sprout and guides the sprout. gene expression occurring in periods or cycles that are repeated frequently (i.e., every 2 h) throughout a 24-h period. de novo formation of blood vessels from the local differentiation of ECs." @default.
• W2003307217 created "2016-06-24" @default.
• W2003307217 creator A5010502376 @default.
• W2003307217 creator A5029424457 @default.
• W2003307217 creator A5033840220 @default.
• W2003307217 creator A5041811551 @default.
• W2003307217 creator A5054685776 @default.
• W2003307217 date "2013-03-01" @default.
• W2003307217 modified "2023-10-18" @default.
• W2003307217 title "Robustness in angiogenesis: Notch and BMP shaping waves" @default.
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