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- W2003308566 abstract "Ca2+ ions are known to enter skeletal muscle cells at rest and during activity. Except for the well characterized voltage-gated Ca2+ entry through L-type channels, the pathways involved in these Ca2+ entries remain elusive in adult muscle. The present study aimed at investigating Ca2+ influx at rest and during activity using the method of Mn2+ quenching of fura-2 fluorescence on enzymatically isolated mouse muscle cells under voltage control. The rate of quenching induced by Mn2+ influx was found to be dependent on external [Mn2+] and on membrane potential. At -80 mV replacement of Mg2+ by Mn2+ gave rise to an outward current associated with an increase in the cell input resistance. Calibration of the fura-2 response in ionomycin-permeabilized cells indicated that the Mn2+ influx was too small to be resolved as a macroscopic current. Partial depletion of the sarcoplasmic reticulum (SR) induced by train of action potentials in the presence of the SR-ATPase inhibitor cyclopiazonic acid led to a slight increase in the resting Mn2+ influx but was not associated with a change in cell input resistance and membrane potential. Trains of action potentials per se considerably increased Mn2+ entry. The measurement of the voltage dependence of the Mn2+ influx induced by depolarization steps in the presence or absence of the L-type channel blocker Cd2+ indicated that Mn2+ influx induced by depolarization occurred through L-type channels and through a parallel distinct and electrically silent voltage-gated pathway which may provide 30 % of the global Mn2+ influx at +30 mV. This work was supported by the Université Lyon 1, the Centre National de la Recherche Scientifique, the Association Française contre les Myopathies and the Agence Nationale de la Recherche Maladies Rares." @default.
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- W2003308566 date "2009-02-01" @default.
- W2003308566 modified "2023-10-18" @default.
- W2003308566 title "Divalent Cation Current And Influx Investigated By The Mn2+ Quenching Method In Resting And Active Voltage-Controlled Mouse Skeletal Muscle Fibres" @default.
- W2003308566 doi "https://doi.org/10.1016/j.bpj.2008.12.1153" @default.
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