Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003308704> ?p ?o ?g. }
- W2003308704 endingPage "974" @default.
- W2003308704 startingPage "963" @default.
- W2003308704 abstract "How cells maintain their ploidy is relevant to cellular development and disease. Here, we investigate the mechanism by which the bacterium Bacillus subtilis enforces diploidy as it differentiates into a dormant spore. We demonstrate that a sporulation-induced protein SirA (originally annotated YneE) blocks new rounds of replication by targeting the highly conserved replication initiation factor DnaA. We show that SirA interacts with DnaA and displaces it from the replication origin. As a result, expression of SirA during growth rapidly blocks replication and causes cell death in a DnaA-dependent manner. Finally, cells lacking SirA over-replicate during sporulation. These results support a model in which induction of SirA enforces diploidy by inhibiting replication initiation as B. subtilis cells develop into spores." @default.
- W2003308704 created "2016-06-24" @default.
- W2003308704 creator A5035658080 @default.
- W2003308704 creator A5065212721 @default.
- W2003308704 creator A5084055425 @default.
- W2003308704 date "2009-08-24" @default.
- W2003308704 modified "2023-10-01" @default.
- W2003308704 title "SirA enforces diploidy by inhibiting the replication initiator DnaA during spore formation in<i>Bacillus subtilis</i>" @default.
- W2003308704 cites W1497138669 @default.
- W2003308704 cites W1522024616 @default.
- W2003308704 cites W1544509679 @default.
- W2003308704 cites W1547209925 @default.
- W2003308704 cites W1891149748 @default.
- W2003308704 cites W1942644614 @default.
- W2003308704 cites W1966901276 @default.
- W2003308704 cites W1970203866 @default.
- W2003308704 cites W1971663668 @default.
- W2003308704 cites W1976293898 @default.
- W2003308704 cites W1988679341 @default.
- W2003308704 cites W2007839457 @default.
- W2003308704 cites W2010040997 @default.
- W2003308704 cites W2017716401 @default.
- W2003308704 cites W2020657021 @default.
- W2003308704 cites W2021150294 @default.
- W2003308704 cites W2021606207 @default.
- W2003308704 cites W2029897974 @default.
- W2003308704 cites W2029920657 @default.
- W2003308704 cites W2032145856 @default.
- W2003308704 cites W2032209646 @default.
- W2003308704 cites W2034750183 @default.
- W2003308704 cites W2040155202 @default.
- W2003308704 cites W2047589389 @default.
- W2003308704 cites W2052205534 @default.
- W2003308704 cites W2059349322 @default.
- W2003308704 cites W2059723324 @default.
- W2003308704 cites W2070856482 @default.
- W2003308704 cites W2076342303 @default.
- W2003308704 cites W2080673872 @default.
- W2003308704 cites W2084208246 @default.
- W2003308704 cites W2086488637 @default.
- W2003308704 cites W2092802908 @default.
- W2003308704 cites W2095734429 @default.
- W2003308704 cites W2099604042 @default.
- W2003308704 cites W2103508212 @default.
- W2003308704 cites W2103682783 @default.
- W2003308704 cites W2108294778 @default.
- W2003308704 cites W2110260644 @default.
- W2003308704 cites W2111020173 @default.
- W2003308704 cites W2114353033 @default.
- W2003308704 cites W2116416010 @default.
- W2003308704 cites W2125343901 @default.
- W2003308704 cites W2145669912 @default.
- W2003308704 cites W2149456142 @default.
- W2003308704 cites W2165096694 @default.
- W2003308704 cites W2167132683 @default.
- W2003308704 cites W4248345907 @default.
- W2003308704 doi "https://doi.org/10.1111/j.1365-2958.2009.06825.x" @default.
- W2003308704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2992877" @default.
- W2003308704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19682252" @default.
- W2003308704 hasPublicationYear "2009" @default.
- W2003308704 type Work @default.
- W2003308704 sameAs 2003308704 @default.
- W2003308704 citedByCount "73" @default.
- W2003308704 countsByYear W20033087042012 @default.
- W2003308704 countsByYear W20033087042013 @default.
- W2003308704 countsByYear W20033087042014 @default.
- W2003308704 countsByYear W20033087042015 @default.
- W2003308704 countsByYear W20033087042016 @default.
- W2003308704 countsByYear W20033087042017 @default.
- W2003308704 countsByYear W20033087042018 @default.
- W2003308704 countsByYear W20033087042019 @default.
- W2003308704 countsByYear W20033087042020 @default.
- W2003308704 countsByYear W20033087042021 @default.
- W2003308704 countsByYear W20033087042022 @default.
- W2003308704 countsByYear W20033087042023 @default.
- W2003308704 crossrefType "journal-article" @default.
- W2003308704 hasAuthorship W2003308704A5035658080 @default.
- W2003308704 hasAuthorship W2003308704A5065212721 @default.
- W2003308704 hasAuthorship W2003308704A5084055425 @default.
- W2003308704 hasBestOaLocation W20033087041 @default.
- W2003308704 hasConcept C104317684 @default.
- W2003308704 hasConcept C107827726 @default.
- W2003308704 hasConcept C12590798 @default.
- W2003308704 hasConcept C143191323 @default.
- W2003308704 hasConcept C159047783 @default.
- W2003308704 hasConcept C174618031 @default.
- W2003308704 hasConcept C2777272437 @default.
- W2003308704 hasConcept C523546767 @default.
- W2003308704 hasConcept C54355233 @default.
- W2003308704 hasConcept C552990157 @default.
- W2003308704 hasConcept C58337764 @default.
- W2003308704 hasConcept C73573662 @default.
- W2003308704 hasConcept C86803240 @default.
- W2003308704 hasConcept C89423630 @default.
- W2003308704 hasConcept C95444343 @default.
- W2003308704 hasConceptScore W2003308704C104317684 @default.
- W2003308704 hasConceptScore W2003308704C107827726 @default.
- W2003308704 hasConceptScore W2003308704C12590798 @default.