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• W2003313303 abstract "The mammalian visual cortex is organized into columns. Here, we examine cortical influences upon developing visual afferents in the cat by altering intrinsic gamma-aminobutyric acid (GABA)-mediated inhibition with benzodiazepines. Local enhancement by agonist (diazepam) infusion did not perturb visual responsiveness, but did widen column spacing. An inverse agonist (DMCM) produced the opposite effect. Thus, intracortical inhibitory circuits shape the geometry of incoming thalamic arbors, suggesting that cortical columnar architecture depends on neuronal activity." @default.
• W2003313303 created "2016-06-24" @default.
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• W2003313303 date "2004-03-12" @default.
• W2003313303 modified "2023-09-26" @default.
• W2003313303 title "Columnar Architecture Sculpted by GABA Circuits in Developing Cat Visual Cortex" @default.
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• W2003313303 doi "https://doi.org/10.1126/science.1091031" @default.
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