FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003325573> ?p ?o ?g. }

• W2003325573 endingPage "e000181" @default.
• W2003325573 startingPage "e000181" @default.
• W2003325573 abstract "<h3>Background</h3> There is growing interest in the potential utility of real-time PCR in diagnosing bloodstream infection by detecting pathogen DNA in blood samples within a few hours. SeptiFast is a multipathogen probe-based real-time PCR system targeting ribosomal DNA sequences of bacteria and fungi. It detects and identifies the commonest pathogens causing bloodstream infection and has European regulatory approval. The SeptiFast pathogen panel is suited to identifying healthcare-associated bloodstream infection acquired during complex healthcare, and the authors report here the protocol for the first detailed health-technology assessment of multiplex real-time PCR in this setting. <h3>Methods/design</h3> A Phase III multicentre double-blinded diagnostic study will determine the clinical validity of SeptiFast for the rapid detection of healthcare-associated bloodstream infection, against the current service standard of microbiological culture, in an adequately sized population of critically ill adult patients. Results from SeptiFast and standard microbiological culture procedures in each patient will be compared at study conclusion and the metrics of clinical diagnostic accuracy of SeptiFast determined in this population setting. In addition, this study aims to assess further the preliminary evidence that the detection of pathogen DNA in the bloodstream using SeptiFast may have value in identifying the presence of infection elsewhere in the body. Furthermore, differences in circulating immune-inflammatory markers in patient groups differentiated by the presence/absence of culturable pathogens and pathogen DNA will help elucidate further the patho-physiology of infection developing in the critically ill. <h3>Ethics and dissemination</h3> Ethical approval has been granted by the North West 6 Research Ethics Committee (09/H1003/109). Based on the results of this first non-commercial study, independent recommendations will be made to The Department of Health (open-access health technology assessment report) as to whether SeptiFast has sufficient clinical diagnostic accuracy to move forward to efficacy testing during the provision of routine clinical care." @default.
• W2003325573 created "2016-06-24" @default.
• W2003325573 creator A5002936880 @default.
• W2003325573 creator A5005251466 @default.
• W2003325573 creator A5015055244 @default.
• W2003325573 creator A5040744360 @default.
• W2003325573 creator A5046415947 @default.
• W2003325573 creator A5059014594 @default.
• W2003325573 creator A5072521764 @default.
• W2003325573 date "2011-06-30" @default.
• W2003325573 modified "2023-09-27" @default.
• W2003325573 title "The clinical diagnostic accuracy of rapid detection of healthcare-associated bloodstream infection in intensive care using multipathogen real-time PCR technology" @default.
• W2003325573 cites W1531730344 @default.
• W2003325573 cites W1920090547 @default.
• W2003325573 cites W1981610944 @default.
• W2003325573 cites W1993397663 @default.
• W2003325573 cites W2005896876 @default.
• W2003325573 cites W2014093593 @default.
• W2003325573 cites W2022961959 @default.
• W2003325573 cites W2047632277 @default.
• W2003325573 cites W2099209328 @default.
• W2003325573 cites W2099673297 @default.
• W2003325573 cites W2112137655 @default.
• W2003325573 cites W2127774299 @default.
• W2003325573 cites W2134689623 @default.
• W2003325573 cites W2150230939 @default.
• W2003325573 cites W2151426785 @default.
• W2003325573 cites W2156576848 @default.
• W2003325573 cites W2165158988 @default.
• W2003325573 cites W2171155970 @default.
• W2003325573 cites W613025273 @default.
• W2003325573 doi "https://doi.org/10.1136/bmjopen-2011-000181" @default.
• W2003325573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191580" @default.
• W2003325573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22021785" @default.
• W2003325573 hasPublicationYear "2011" @default.
• W2003325573 type Work @default.
• W2003325573 sameAs 2003325573 @default.
• W2003325573 citedByCount "22" @default.
• W2003325573 countsByYear W20033255732012 @default.
• W2003325573 countsByYear W20033255732013 @default.
• W2003325573 countsByYear W20033255732014 @default.
• W2003325573 countsByYear W20033255732015 @default.
• W2003325573 countsByYear W20033255732016 @default.
• W2003325573 countsByYear W20033255732017 @default.
• W2003325573 countsByYear W20033255732018 @default.
• W2003325573 countsByYear W20033255732021 @default.
• W2003325573 crossrefType "journal-article" @default.
• W2003325573 hasAuthorship W2003325573A5002936880 @default.
• W2003325573 hasAuthorship W2003325573A5005251466 @default.
• W2003325573 hasAuthorship W2003325573A5015055244 @default.
• W2003325573 hasAuthorship W2003325573A5040744360 @default.
• W2003325573 hasAuthorship W2003325573A5046415947 @default.
• W2003325573 hasAuthorship W2003325573A5059014594 @default.
• W2003325573 hasAuthorship W2003325573A5072521764 @default.
• W2003325573 hasBestOaLocation W20033255731 @default.
• W2003325573 hasConcept C104317684 @default.
• W2003325573 hasConcept C160735492 @default.
• W2003325573 hasConcept C162324750 @default.
• W2003325573 hasConcept C177713679 @default.
• W2003325573 hasConcept C203014093 @default.
• W2003325573 hasConcept C2776460866 @default.
• W2003325573 hasConcept C2779473907 @default.
• W2003325573 hasConcept C2908647359 @default.
• W2003325573 hasConcept C2987404301 @default.
• W2003325573 hasConcept C2991859549 @default.
• W2003325573 hasConcept C3018946976 @default.
• W2003325573 hasConcept C49105822 @default.
• W2003325573 hasConcept C501593827 @default.
• W2003325573 hasConcept C50522688 @default.
• W2003325573 hasConcept C55493867 @default.
• W2003325573 hasConcept C71924100 @default.
• W2003325573 hasConcept C86803240 @default.
• W2003325573 hasConcept C89423630 @default.
• W2003325573 hasConcept C90583042 @default.
• W2003325573 hasConcept C99454951 @default.
• W2003325573 hasConceptScore W2003325573C104317684 @default.
• W2003325573 hasConceptScore W2003325573C160735492 @default.
• W2003325573 hasConceptScore W2003325573C162324750 @default.
• W2003325573 hasConceptScore W2003325573C177713679 @default.
• W2003325573 hasConceptScore W2003325573C203014093 @default.
• W2003325573 hasConceptScore W2003325573C2776460866 @default.
• W2003325573 hasConceptScore W2003325573C2779473907 @default.
• W2003325573 hasConceptScore W2003325573C2908647359 @default.
• W2003325573 hasConceptScore W2003325573C2987404301 @default.
• W2003325573 hasConceptScore W2003325573C2991859549 @default.
• W2003325573 hasConceptScore W2003325573C3018946976 @default.
• W2003325573 hasConceptScore W2003325573C49105822 @default.
• W2003325573 hasConceptScore W2003325573C501593827 @default.
• W2003325573 hasConceptScore W2003325573C50522688 @default.
• W2003325573 hasConceptScore W2003325573C55493867 @default.
• W2003325573 hasConceptScore W2003325573C71924100 @default.
• W2003325573 hasConceptScore W2003325573C86803240 @default.
• W2003325573 hasConceptScore W2003325573C89423630 @default.
• W2003325573 hasConceptScore W2003325573C90583042 @default.
• W2003325573 hasConceptScore W2003325573C99454951 @default.
• W2003325573 hasIssue "1" @default.
• W2003325573 hasLocation W20033255731 @default.
• W2003325573 hasLocation W20033255732 @default.

• next