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- W2003342802 endingPage "e115066" @default.
- W2003342802 startingPage "e115066" @default.
- W2003342802 abstract "Burkholderia mallei and Burkholderia pseudomallei are potentially lethal pathogens categorized as biothreat agents due, in part, to their ability to be disseminated via aerosol. There are no protective vaccines against these pathogens and treatment options are limited and cumbersome. Since disease severity is greatest when these agents are inhaled, efforts to develop pre- or post-exposure prophylaxis focus largely on inhalation models of infection. Here, we demonstrate a non-invasive and technically simple method for affecting the inhalational challenge of BALB/c mice with B. pseudomallei and B. mallei. In this model, two investigators utilized common laboratory tools such as forceps and a micropipette to conduct and characterize an effective and reproducible inhalational challenge of BALB/c mice with B. mallei and B. pseudomallei. Challenge by oropharyngeal aspiration resulted in acute disease. Additionally, 50% endpoints for B. pseudomallei K96243 and B. mallei ATCC 23344 were nearly identical to published aerosol challenge methods. Furthermore, the pathogens disseminated to all major organs typically targeted by these agents where they proliferated. The pro-inflammatory cytokine production in the proximal and peripheral fluids demonstrated a rapid and robust immune response comparable to previously described murine and human studies. These observations demonstrate that OA is a viable alternative to aerosol exposure." @default.
- W2003342802 created "2016-06-24" @default.
- W2003342802 creator A5061909361 @default.
- W2003342802 creator A5071238670 @default.
- W2003342802 creator A5072817318 @default.
- W2003342802 creator A5091067654 @default.
- W2003342802 date "2014-12-11" @default.
- W2003342802 modified "2023-10-17" @default.
- W2003342802 title "Oropharyngeal Aspiration of Burkholderia mallei and Burkholderia pseudomallei in BALB/c Mice" @default.
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- W2003342802 doi "https://doi.org/10.1371/journal.pone.0115066" @default.
- W2003342802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4263729" @default.
- W2003342802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25503969" @default.
- W2003342802 hasPublicationYear "2014" @default.
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