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• W2003345937 endingPage "339" @default.
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• W2003345937 abstract "The identification of novel drug targets is one of the major challenges in proteomics. Computational methods developed over the last decade have enhanced the process of drug design in both terms of time and quality. The main task is the design of selective compounds, which bind targets more specifically, dependent on the desired mode of action of the particular drug. This makes it necessary to create compounds, which either exhibit their functions on one single protein to exclude undesired cross-reactivity or to use the advantageous effect of less selective drugs that target numerous proteins and therefore exhibit their functions on whole protein classes. Main aspects in the assignment of interactions between ligands and putative targets involve the amino acid composition of the binding site, evolutionary conservation and similarity in sequence and structure of known targets. Similarities or differences within classified protein families can be the key to their function and give first hints to functional drug design. Hereby, binding site-based classification outnumbers sequence-based classifications since similar binding sites can also be found in more distant proteins. Membrane proteins are ‘difficult targets’, because of their special physicochemical characteristics and the general lack of structural information. Here, we describe recent advances in modeling methods dedicated to membrane proteins. Different descriptors of similarity between compounds and the similarity between binding sites are under development and elucidate important aspects like dynamics or entropy. The importance of computational drug design is undisputable. Nevertheless, the process of design is complicated by increasing complexity, which underlines the importance of accurate knowledge about the addressed target class(es) and particularly their binding sites. One main objective by considering named topics is to predict putative side effects and errant functions (off-target effects) of novel drugs, which requires a holistic (systems biology) view on drug-target-pathway relations. In the following, we give a brief summary about the recent discussion on drug–target interactions with emphasis on membrane proteins." @default.
• W2003345937 created "2016-06-24" @default.
• W2003345937 creator A5027667039 @default.
• W2003345937 creator A5043414157 @default.
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• W2003345937 creator A5067057792 @default.
• W2003345937 creator A5077997638 @default.
• W2003345937 creator A5090164972 @default.
• W2003345937 date "2012-04-01" @default.
• W2003345937 modified "2023-10-02" @default.
• W2003345937 title "Binding sites in membrane proteins – Diversity, druggability and prospects" @default.
• W2003345937 cites W1133356780 @default.
• W2003345937 cites W1504533062 @default.
• W2003345937 cites W1825353903 @default.
• W2003345937 cites W1895993106 @default.
• W2003345937 cites W1908561802 @default.
• W2003345937 cites W1920052317 @default.
• W2003345937 cites W1964048941 @default.
• W2003345937 cites W1968682237 @default.
• W2003345937 cites W1970332489 @default.
• W2003345937 cites W1973448386 @default.
• W2003345937 cites W1974477738 @default.
• W2003345937 cites W1975358692 @default.
• W2003345937 cites W1975740938 @default.
• W2003345937 cites W1977473142 @default.
• W2003345937 cites W1989971979 @default.
• W2003345937 cites W1990289691 @default.
• W2003345937 cites W1993976538 @default.
• W2003345937 cites W1995528018 @default.
• W2003345937 cites W1996113142 @default.
• W2003345937 cites W2001195760 @default.
• W2003345937 cites W2004175162 @default.
• W2003345937 cites W2006436808 @default.
• W2003345937 cites W2006719424 @default.
• W2003345937 cites W2006964552 @default.
• W2003345937 cites W2009081245 @default.
• W2003345937 cites W2015214828 @default.
• W2003345937 cites W2021954541 @default.
• W2003345937 cites W2027345286 @default.
• W2003345937 cites W2031004942 @default.
• W2003345937 cites W2031194866 @default.
• W2003345937 cites W2034395399 @default.
• W2003345937 cites W2041566506 @default.
• W2003345937 cites W2042239308 @default.
• W2003345937 cites W2047544230 @default.
• W2003345937 cites W2048302799 @default.
• W2003345937 cites W2048695489 @default.
• W2003345937 cites W2049454409 @default.
• W2003345937 cites W2051175490 @default.
• W2003345937 cites W2054118966 @default.
• W2003345937 cites W2056449835 @default.
• W2003345937 cites W2056884349 @default.
• W2003345937 cites W2059890422 @default.
• W2003345937 cites W2061384339 @default.
• W2003345937 cites W2063194349 @default.
• W2003345937 cites W2064399386 @default.
• W2003345937 cites W2065283382 @default.
• W2003345937 cites W2069293737 @default.
• W2003345937 cites W2074192927 @default.
• W2003345937 cites W2077308209 @default.
• W2003345937 cites W2080584551 @default.
• W2003345937 cites W2085144661 @default.
• W2003345937 cites W2085277871 @default.
• W2003345937 cites W2086687315 @default.
• W2003345937 cites W2090699441 @default.
• W2003345937 cites W2091471302 @default.
• W2003345937 cites W2093406448 @default.
• W2003345937 cites W2096960798 @default.
• W2003345937 cites W2099182237 @default.
• W2003345937 cites W2100147128 @default.
• W2003345937 cites W2101223914 @default.
• W2003345937 cites W2102513649 @default.
• W2003345937 cites W2103017472 @default.
• W2003345937 cites W2103397308 @default.
• W2003345937 cites W2103935162 @default.
• W2003345937 cites W2104477830 @default.
• W2003345937 cites W2104961861 @default.
• W2003345937 cites W2108069034 @default.
• W2003345937 cites W2110586207 @default.
• W2003345937 cites W2111078532 @default.
• W2003345937 cites W2112109058 @default.
• W2003345937 cites W2112878061 @default.
• W2003345937 cites W2120138074 @default.
• W2003345937 cites W2127031801 @default.
• W2003345937 cites W2127102885 @default.
• W2003345937 cites W2127648442 @default.
• W2003345937 cites W2127654342 @default.
• W2003345937 cites W2128768874 @default.
• W2003345937 cites W2131203281 @default.
• W2003345937 cites W2136280642 @default.
• W2003345937 cites W2137071423 @default.
• W2003345937 cites W2137450588 @default.
• W2003345937 cites W2137991504 @default.
• W2003345937 cites W2138512826 @default.
• W2003345937 cites W2139694010 @default.
• W2003345937 cites W2143078152 @default.
• W2003345937 cites W2144258433 @default.
• W2003345937 cites W2146224808 @default.

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