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• W2003371953 abstract "An efficient and economical method was developed for the synthesis of 3-substituted indoles by one-pot three-component coupling reaction of a substituted or unsubstituted benzaldehyde, N-methylaniline, and indole or N-methylindole using Yb(OTf)(3)-SiO(2) as a catalyst. All the synthesized compounds were evaluated for inhibition of cell proliferation of human colon carcinoma (HT-29), human ovarian adenocarcinoma (SK-OV-3), and c-Src kinase activity. The 4-methylphenyl (4o and 4p) and 4-methoxyphenyl (4q) indole derivatives inhibited the cell proliferation of SK-OV-3 and HT-29 cells by 70-77% at a concentration of 50 μM. The unsubstituted phenyl (4d) and 3-nitrophenyl (4l) derivatives showed the inhibition of c-Src kinase with IC(50) values of 50.6 and 58.3 μM, respectively." @default.
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• W2003371953 date "2011-06-01" @default.
• W2003371953 modified "2023-10-16" @default.
• W2003371953 title "3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities" @default.
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• W2003371953 doi "https://doi.org/10.1016/j.bmcl.2011.05.010" @default.
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