FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003375498> ?p ?o ?g. }

• W2003375498 endingPage "e110913" @default.
• W2003375498 startingPage "e110913" @default.
• W2003375498 abstract "Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires systems approaches for deeper elucidation of the underlying molecular mechanisms. In this paper we develop a mechanistic model for single- and multi-site phosphorylation. The proposed model is compared with previously reported studies. We compare the predictions of our model with experiments published in the literature in the context of inflammatory signaling events in order to provide a mechanistic description of the multisite phosphorylation-mediated regulation of Signal Transducer and Activator of Transcription 3 (STAT3) and Interferon Regulatory Factor 5 (IRF-5) proteins. The presented model makes crucial predictions for transcription factor phosphorylation events in the immune system. The model proposes potential mechanisms for T cell phenotype switching and production of cytokines. This study also provides a generic framework for the better understanding of a large number of multisite phosphorylation-regulated biochemical circuits." @default.
• W2003375498 created "2016-06-24" @default.
• W2003375498 creator A5007473862 @default.
• W2003375498 creator A5021253350 @default.
• W2003375498 creator A5026207697 @default.
• W2003375498 creator A5028511836 @default.
• W2003375498 creator A5033761162 @default.
• W2003375498 creator A5049630802 @default.
• W2003375498 date "2014-10-21" @default.
• W2003375498 modified "2023-10-02" @default.
• W2003375498 title "A Systems Model of Phosphorylation for Inflammatory Signaling Events" @default.
• W2003375498 cites W108809021 @default.
• W2003375498 cites W1483093256 @default.
• W2003375498 cites W1527011538 @default.
• W2003375498 cites W1560154291 @default.
• W2003375498 cites W1740603564 @default.
• W2003375498 cites W1967369695 @default.
• W2003375498 cites W1970308473 @default.
• W2003375498 cites W1977008063 @default.
• W2003375498 cites W1978930058 @default.
• W2003375498 cites W1989588757 @default.
• W2003375498 cites W1990026555 @default.
• W2003375498 cites W1990323057 @default.
• W2003375498 cites W1993034428 @default.
• W2003375498 cites W1994500037 @default.
• W2003375498 cites W2000619385 @default.
• W2003375498 cites W2003681585 @default.
• W2003375498 cites W2008855387 @default.
• W2003375498 cites W2016291752 @default.
• W2003375498 cites W2017226171 @default.
• W2003375498 cites W2018322688 @default.
• W2003375498 cites W2035718151 @default.
• W2003375498 cites W2037001860 @default.
• W2003375498 cites W2038327886 @default.
• W2003375498 cites W2041603328 @default.
• W2003375498 cites W2041756411 @default.
• W2003375498 cites W2043261093 @default.
• W2003375498 cites W2045575961 @default.
• W2003375498 cites W2050207496 @default.
• W2003375498 cites W2052949314 @default.
• W2003375498 cites W2056512813 @default.
• W2003375498 cites W2065206333 @default.
• W2003375498 cites W2068289643 @default.
• W2003375498 cites W2070658593 @default.
• W2003375498 cites W2070685885 @default.
• W2003375498 cites W2073580835 @default.
• W2003375498 cites W2075895484 @default.
• W2003375498 cites W2081107312 @default.
• W2003375498 cites W2083802827 @default.
• W2003375498 cites W2088087948 @default.
• W2003375498 cites W2090481070 @default.
• W2003375498 cites W2098071985 @default.
• W2003375498 cites W2102247469 @default.
• W2003375498 cites W2104726963 @default.
• W2003375498 cites W2105191150 @default.
• W2003375498 cites W2106128014 @default.
• W2003375498 cites W2116570389 @default.
• W2003375498 cites W2118390739 @default.
• W2003375498 cites W2120532339 @default.
• W2003375498 cites W2126464248 @default.
• W2003375498 cites W2127013244 @default.
• W2003375498 cites W2138071931 @default.
• W2003375498 cites W2145225614 @default.
• W2003375498 cites W2145478309 @default.
• W2003375498 cites W2152014155 @default.
• W2003375498 cites W2152532651 @default.
• W2003375498 cites W2159228404 @default.
• W2003375498 cites W2159659449 @default.
• W2003375498 cites W2165591553 @default.
• W2003375498 cites W2169125400 @default.
• W2003375498 doi "https://doi.org/10.1371/journal.pone.0110913" @default.
• W2003375498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4205014" @default.
• W2003375498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25333362" @default.
• W2003375498 hasPublicationYear "2014" @default.
• W2003375498 type Work @default.
• W2003375498 sameAs 2003375498 @default.
• W2003375498 citedByCount "8" @default.
• W2003375498 countsByYear W20033754982015 @default.
• W2003375498 countsByYear W20033754982016 @default.
• W2003375498 countsByYear W20033754982017 @default.
• W2003375498 countsByYear W20033754982019 @default.
• W2003375498 countsByYear W20033754982021 @default.
• W2003375498 countsByYear W20033754982023 @default.
• W2003375498 crossrefType "journal-article" @default.
• W2003375498 hasAuthorship W2003375498A5007473862 @default.
• W2003375498 hasAuthorship W2003375498A5021253350 @default.
• W2003375498 hasAuthorship W2003375498A5026207697 @default.
• W2003375498 hasAuthorship W2003375498A5028511836 @default.
• W2003375498 hasAuthorship W2003375498A5033761162 @default.
• W2003375498 hasAuthorship W2003375498A5049630802 @default.
• W2003375498 hasBestOaLocation W20033754981 @default.
• W2003375498 hasConcept C104317684 @default.
• W2003375498 hasConcept C104551158 @default.
• W2003375498 hasConcept C11960822 @default.
• W2003375498 hasConcept C151730666 @default.
• W2003375498 hasConcept C152662350 @default.
• W2003375498 hasConcept C171958077 @default.
• W2003375498 hasConcept C2778923194 @default.

• next