FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003377812> ?p ?o ?g. }

• W2003377812 endingPage "215" @default.
• W2003377812 startingPage "210" @default.
• W2003377812 abstract "The use of tyrosine kinase inhibitors (TKIs) has resulted in successful treatment of KIT-positive neoplasms. Carcinosarcoma is a very aggressive neoplasm. Consequently, c-kit expression may have significant clinical implications for this tumor. The purpose of the present study was to assess c-kit expression in the carcinomatous and sarcomatous element of carcinosarcoma to identify if KIT represents a therapeutic target for treatment of this neoplasm.Immunohistochemical staining for c-KIT was performed on paraffin-embedded tissue blocks of 20 consecutive uterine specimens with carcinosarcoma, 40 with endometrial carcinoma, and 12 with atrophic endometrium. Two pathologists assessed the scoring index of staining.In the stromal element of carcinosarcoma, no immunohistochemically c-KIT stained cells were observed and in the epithelial element, a low scoring index of staining was present. In endometrial endometrioid carcinoma, the scoring index was high in only 15% of the specimens. In the atrophic endometrium, a low scoring index was seen in all specimens.Our results seem to suggest that c-kit probably plays no major role in the pathogenesis of the majority of these tumors while it may be involved in the pathogenesis of some endometrial carcinomas. In view of the multiple molecular targets that are activated by imatinib mesylate, no definitive conclusions can be drawn with regard its effectiveness in carcinosarcomas based on the present study. Further studies of c-kit expression in larger series of carcinosarcomas in order to settle the controversial issues with regard to frequency of expression, prognostic, and clinical value are warranted." @default.
• W2003377812 created "2016-06-24" @default.
• W2003377812 creator A5017971967 @default.
• W2003377812 creator A5041578969 @default.
• W2003377812 creator A5061136502 @default.
• W2003377812 creator A5067538930 @default.
• W2003377812 creator A5071124939 @default.
• W2003377812 creator A5091569816 @default.
• W2003377812 date "2005-01-01" @default.
• W2003377812 modified "2023-10-18" @default.
• W2003377812 title "Expression of c-kit in uterine carcinosarcoma" @default.
• W2003377812 cites W1752312133 @default.
• W2003377812 cites W1968475205 @default.
• W2003377812 cites W1975507162 @default.
• W2003377812 cites W1975522603 @default.
• W2003377812 cites W1976313495 @default.
• W2003377812 cites W1991113818 @default.
• W2003377812 cites W2000507573 @default.
• W2003377812 cites W2005022280 @default.
• W2003377812 cites W2007328596 @default.
• W2003377812 cites W2014300063 @default.
• W2003377812 cites W2031209812 @default.
• W2003377812 cites W2038596108 @default.
• W2003377812 cites W2046551180 @default.
• W2003377812 cites W2047381692 @default.
• W2003377812 cites W2058269118 @default.
• W2003377812 cites W2065618440 @default.
• W2003377812 cites W2068953119 @default.
• W2003377812 cites W2073547414 @default.
• W2003377812 cites W2091394697 @default.
• W2003377812 cites W2093166533 @default.
• W2003377812 cites W2095174304 @default.
• W2003377812 cites W2100784179 @default.
• W2003377812 cites W2110083837 @default.
• W2003377812 cites W2113589296 @default.
• W2003377812 cites W2133146038 @default.
• W2003377812 cites W2151527507 @default.
• W2003377812 cites W2151900782 @default.
• W2003377812 cites W2163043462 @default.
• W2003377812 cites W2312804644 @default.
• W2003377812 cites W2412572396 @default.
• W2003377812 cites W4247813653 @default.
• W2003377812 cites W55398840 @default.
• W2003377812 doi "https://doi.org/10.1016/j.ygyno.2004.09.045" @default.
• W2003377812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15589603" @default.
• W2003377812 hasPublicationYear "2005" @default.
• W2003377812 type Work @default.
• W2003377812 sameAs 2003377812 @default.
• W2003377812 citedByCount "20" @default.
• W2003377812 countsByYear W20033778122012 @default.
• W2003377812 countsByYear W20033778122015 @default.
• W2003377812 countsByYear W20033778122016 @default.
• W2003377812 countsByYear W20033778122019 @default.
• W2003377812 countsByYear W20033778122020 @default.
• W2003377812 countsByYear W20033778122021 @default.
• W2003377812 countsByYear W20033778122023 @default.
• W2003377812 crossrefType "journal-article" @default.
• W2003377812 hasAuthorship W2003377812A5017971967 @default.
• W2003377812 hasAuthorship W2003377812A5041578969 @default.
• W2003377812 hasAuthorship W2003377812A5061136502 @default.
• W2003377812 hasAuthorship W2003377812A5067538930 @default.
• W2003377812 hasAuthorship W2003377812A5071124939 @default.
• W2003377812 hasAuthorship W2003377812A5091569816 @default.
• W2003377812 hasConcept C142724271 @default.
• W2003377812 hasConcept C16930146 @default.
• W2003377812 hasConcept C204232928 @default.
• W2003377812 hasConcept C2776085573 @default.
• W2003377812 hasConcept C2777546739 @default.
• W2003377812 hasConcept C2778938455 @default.
• W2003377812 hasConcept C2780635560 @default.
• W2003377812 hasConcept C2780942790 @default.
• W2003377812 hasConcept C71924100 @default.
• W2003377812 hasConcept C74864618 @default.
• W2003377812 hasConceptScore W2003377812C142724271 @default.
• W2003377812 hasConceptScore W2003377812C16930146 @default.
• W2003377812 hasConceptScore W2003377812C204232928 @default.
• W2003377812 hasConceptScore W2003377812C2776085573 @default.
• W2003377812 hasConceptScore W2003377812C2777546739 @default.
• W2003377812 hasConceptScore W2003377812C2778938455 @default.
• W2003377812 hasConceptScore W2003377812C2780635560 @default.
• W2003377812 hasConceptScore W2003377812C2780942790 @default.
• W2003377812 hasConceptScore W2003377812C71924100 @default.
• W2003377812 hasConceptScore W2003377812C74864618 @default.
• W2003377812 hasIssue "1" @default.
• W2003377812 hasLocation W20033778121 @default.
• W2003377812 hasLocation W20033778122 @default.
• W2003377812 hasOpenAccess W2003377812 @default.
• W2003377812 hasPrimaryLocation W20033778121 @default.
• W2003377812 hasRelatedWork W1717022440 @default.
• W2003377812 hasRelatedWork W2003377812 @default.
• W2003377812 hasRelatedWork W2333758596 @default.
• W2003377812 hasRelatedWork W2398001373 @default.
• W2003377812 hasRelatedWork W2416686029 @default.
• W2003377812 hasRelatedWork W2588648174 @default.
• W2003377812 hasRelatedWork W2949694903 @default.
• W2003377812 hasRelatedWork W3199982648 @default.
• W2003377812 hasRelatedWork W57662741 @default.
• W2003377812 hasRelatedWork W72901766 @default.

• next