FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003384984> ?p ?o ?g. }

• W2003384984 endingPage "1593" @default.
• W2003384984 startingPage "1588" @default.
• W2003384984 abstract "To find new compounds selective for purported I1 imidazoline receptors (I1Rs) over I2 imidazoline binding sites (I2BS) and alpha2-adrenoceptors (alpha2ARs), a series of pyrrolinic isosteres of rilmenidine has been prepared and their biological activity at I1Rs, I2BS, and alpha2ARs evaluated. This isosteric replacement provided us with compounds which still bound to I1Rs but not to I2BS nor to alpha2ARs. A limited structure-affinity relationship was generated around the heterocyclic moiety of these ligands. One compound in this series, LNP 509 (1e) [cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine], had no detectable affinity at alpha2ARs yet was capable of lowering blood pressure after central administration. These pyrrolinic analogues constitute a new chemical class of imidazoline related compounds with high selectivity for the I1Rs. They could be used as new tools in the study of I1Rs and in the conception of new centrally acting hypotensive drugs." @default.
• W2003384984 created "2016-06-24" @default.
• W2003384984 creator A5006448264 @default.
• W2003384984 creator A5012924446 @default.
• W2003384984 creator A5028813621 @default.
• W2003384984 creator A5036700097 @default.
• W2003384984 creator A5051852907 @default.
• W2003384984 creator A5070633501 @default.
• W2003384984 creator A5075440909 @default.
• W2003384984 creator A5077552401 @default.
• W2003384984 creator A5086785993 @default.
• W2003384984 date "2001-03-24" @default.
• W2003384984 modified "2023-10-13" @default.
• W2003384984 title "Synthesis and Biological Evaluation of Pyrrolinic Isosteres of Rilmenidine. Discovery of <i>cis</i>-/<i>trans</i>-Dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3<i>H</i>- pyrrol-2-yl)-amine (LNP 509), an I₁ Imidazoline Receptor Selective Ligand with Hypotensive Activity" @default.
• W2003384984 cites W1962718525 @default.
• W2003384984 cites W1984689203 @default.
• W2003384984 cites W1999634188 @default.
• W2003384984 cites W2005678334 @default.
• W2003384984 cites W2006773867 @default.
• W2003384984 cites W2009059127 @default.
• W2003384984 cites W2014582936 @default.
• W2003384984 cites W2015668465 @default.
• W2003384984 cites W2042404453 @default.
• W2003384984 cites W2043425461 @default.
• W2003384984 cites W2049604222 @default.
• W2003384984 cites W2050370295 @default.
• W2003384984 cites W2069607377 @default.
• W2003384984 cites W2072431227 @default.
• W2003384984 cites W2083992047 @default.
• W2003384984 cites W2089200585 @default.
• W2003384984 cites W2094657631 @default.
• W2003384984 cites W2151609121 @default.
• W2003384984 cites W2317172097 @default.
• W2003384984 cites W2318073724 @default.
• W2003384984 cites W2328703438 @default.
• W2003384984 cites W2894431898 @default.
• W2003384984 cites W2070319416 @default.
• W2003384984 doi "https://doi.org/10.1021/jm001111b" @default.
• W2003384984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11334568" @default.
• W2003384984 hasPublicationYear "2001" @default.
• W2003384984 type Work @default.
• W2003384984 sameAs 2003384984 @default.
• W2003384984 citedByCount "52" @default.
• W2003384984 countsByYear W20033849842012 @default.
• W2003384984 countsByYear W20033849842013 @default.
• W2003384984 countsByYear W20033849842014 @default.
• W2003384984 countsByYear W20033849842015 @default.
• W2003384984 countsByYear W20033849842016 @default.
• W2003384984 countsByYear W20033849842019 @default.
• W2003384984 countsByYear W20033849842020 @default.
• W2003384984 countsByYear W20033849842021 @default.
• W2003384984 countsByYear W20033849842022 @default.
• W2003384984 crossrefType "journal-article" @default.
• W2003384984 hasAuthorship W2003384984A5006448264 @default.
• W2003384984 hasAuthorship W2003384984A5012924446 @default.
• W2003384984 hasAuthorship W2003384984A5028813621 @default.
• W2003384984 hasAuthorship W2003384984A5036700097 @default.
• W2003384984 hasAuthorship W2003384984A5051852907 @default.
• W2003384984 hasAuthorship W2003384984A5070633501 @default.
• W2003384984 hasAuthorship W2003384984A5075440909 @default.
• W2003384984 hasAuthorship W2003384984A5077552401 @default.
• W2003384984 hasAuthorship W2003384984A5086785993 @default.
• W2003384984 hasConcept C114373084 @default.
• W2003384984 hasConcept C116073593 @default.
• W2003384984 hasConcept C118792377 @default.
• W2003384984 hasConcept C123605464 @default.
• W2003384984 hasConcept C131779359 @default.
• W2003384984 hasConcept C161790260 @default.
• W2003384984 hasConcept C170493617 @default.
• W2003384984 hasConcept C178790620 @default.
• W2003384984 hasConcept C185592680 @default.
• W2003384984 hasConcept C193042331 @default.
• W2003384984 hasConcept C202751555 @default.
• W2003384984 hasConcept C21951064 @default.
• W2003384984 hasConcept C2776568683 @default.
• W2003384984 hasConcept C2778938600 @default.
• W2003384984 hasConcept C2780307058 @default.
• W2003384984 hasConcept C3018358672 @default.
• W2003384984 hasConcept C55493867 @default.
• W2003384984 hasConcept C71240020 @default.
• W2003384984 hasConcept C71924100 @default.
• W2003384984 hasConcept C98274493 @default.
• W2003384984 hasConceptScore W2003384984C114373084 @default.
• W2003384984 hasConceptScore W2003384984C116073593 @default.
• W2003384984 hasConceptScore W2003384984C118792377 @default.
• W2003384984 hasConceptScore W2003384984C123605464 @default.
• W2003384984 hasConceptScore W2003384984C131779359 @default.
• W2003384984 hasConceptScore W2003384984C161790260 @default.
• W2003384984 hasConceptScore W2003384984C170493617 @default.
• W2003384984 hasConceptScore W2003384984C178790620 @default.
• W2003384984 hasConceptScore W2003384984C185592680 @default.
• W2003384984 hasConceptScore W2003384984C193042331 @default.
• W2003384984 hasConceptScore W2003384984C202751555 @default.
• W2003384984 hasConceptScore W2003384984C21951064 @default.
• W2003384984 hasConceptScore W2003384984C2776568683 @default.
• W2003384984 hasConceptScore W2003384984C2778938600 @default.
• W2003384984 hasConceptScore W2003384984C2780307058 @default.
• W2003384984 hasConceptScore W2003384984C3018358672 @default.

• next