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• W2003385549 abstract "A series of low molecular weight sialyl-LewisX analogs based on either rigid or flexible replacements for the carbohydrates were designed as orally available anti-inflammatory drugs, synthesized and tested in cell-based adhesion assays. The flexible glycomimetic 7a lacking any glycoside or peptide linkage was prepared in 4 steps and 41% overall yield from methyl 3,5-dihydroxybenzoate and the fucose derivative 18 and exhibited about equal binding affinity to E- and P-selectin compared to the parent tetrasaccharide." @default.
• W2003385549 created "2016-06-24" @default.
• W2003385549 creator A5043026139 @default.
• W2003385549 date "1998-04-01" @default.
• W2003385549 modified "2023-10-16" @default.
• W2003385549 title "Synthesis of novel Sialyl-LewisX glycomimetics as selectin antagonists" @default.
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• W2003385549 doi "https://doi.org/10.1016/s0040-4020(98)00105-7" @default.
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