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- W2003387911 abstract "To investigate the expression leukemia inhibitor factor (LIF), cyclo-oxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), and nitric oxide synthetase (NOS) in the implantation window endometrium of infertile women before IVF cycle to predict the likelihood of successful implantation. Thirty-two infertile women undergoing IVF cycles included the study. The LIF, COX-2, VEGF and NOS staining positivity were compared according to the implantation status (positive and negative). An office hysteroscopy was performed during the implantation window for all infertile women who planned IVF cycles. An endometrial biopsy was taken, and the samples were immunostained for LIF, COX-2, VEGF, and NOS. The patients were divided into two groups according to implantation status. The LIF, COX-2, VEGF and NOS staining positivity between the implantation positive and negative groups were compared. Positively statistically significant LIF and COX-2 antibodies were demonstrated in the implantation positive group. However, there was no difference in VEGF and NOS staining positivity during the implantation period in either group. The prediction of implantation sensitivity, specificity, PPV, and NPV of LIF were 71.4%, 77.8%, 71.4%, and 77.8%, respectively. The sensitivity, specificity, PPV, and NPV of COX-2 were 57.1%, 83.3%, 72.7%, and 71.4%, respectively. LIF and COX-2 in the samples obtained during the implantation window period were positively statistically significant in the implantation positive women prior to the IVF cycle. This indicates that LIF and COX-2 staining positivity in the endometrium during the implantation window may be used as an implantation marker before IVF cycles." @default.
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- W2003387911 date "2013-09-01" @default.
- W2003387911 modified "2023-09-27" @default.
- W2003387911 title "Expression of LIF, COX-2, VEGF, and NOS at the phase of implantation window: predictive markers of IVF outcome" @default.
- W2003387911 doi "https://doi.org/10.1016/j.fertnstert.2013.07.1040" @default.
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