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• W2003388766 abstract "Although there is accumulating evidence that increased formation of reactive nitrogen species in cerebral vasculature contributes to the progression of ischemic damage, but the underlying molecular mechanisms remain elusive. Peroxiredoxin 1 (Prx1) can initiate the antioxidant response by scavenging free radicals. Therefore, we tested the hypothesis that Prx1 regulates the susceptibility to nitrosative stress damage during cerebral ischemia in vitro and in vivo.Proteomic analysis in endothelial cells revealed that Prx1 was upregulated after stress-related oxygen-glucose deprivation (OGD). Although peroxynitrite upregulated Prx1 rapidly, this was followed by its polyubiquitination within 6 h after OGD mediated by the E3 ubiquitin ligase E6-associated protein (E6AP). OGD colocalized E6AP with nitrotyrosine in endothelial cells. To assess translational relevance in vivo, mice were studied after middle cerebral artery occlusion (MCAO). This was accompanied by Prx1 ubiquitination and degradation by the activation of E6AP. Furthermore, brain delivery of a lentiviral vector encoding Prx1 in mice inhibited blood-brain barrier leakage and neuronal damage significantly following MCAO.Nitrosative stress during ischemic insult activates E6AP E3 ubiquitin ligase that ubiquitinates Prx1 and subsequently worsens cerebral damage. Thus, targeting the Prx1 antioxidant defense pathway may represent a novel treatment strategy for neurovascular protection in stroke." @default.
• W2003388766 created "2016-06-24" @default.
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• W2003388766 date "2014-07-01" @default.
• W2003388766 modified "2023-10-18" @default.
• W2003388766 title "Nitrosative Stress Induces Peroxiredoxin 1 Ubiquitination During Ischemic Insult <i>via</i> E6AP Activation in Endothelial Cells Both <i>In Vitro</i> and <i>In Vivo</i>" @default.
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• W2003388766 doi "https://doi.org/10.1089/ars.2013.5381" @default.
• W2003388766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4048580" @default.
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