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- W2003392212 abstract "Recent studies have shown that the cellular immune response to the hypoxic microenvironment constructed by vascular remodeling development modulates the resulting pathologic alterations. A major mechanism mediating adaptive responses to reduced oxygen availability is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1). Impairment of HIF-1-dependent inflammatory responses in T cells causes an augmented vascular remodeling induced by arterial injury, which is shown as prominent neointimal hyperplasia and increase in infiltration of inflammatory cells at the adventitia in mice lacking Hif-1α specifically in T cells. Studies to clarify the mechanism of augmented vascular remodeling in the mutant mice have shown enhanced production of cytokines in activated T cells and augmented antibody production in response to a T-dependent antigen in the mutant mice. This minireview shows that HIF-1α in T cells plays a crucial role in vascular inflammation and remodeling in response to cuff injury as a negative regulator of the T cell-mediated immune response and suggests potential new therapeutic strategies that target HIF-1α." @default.
- W2003392212 created "2016-06-24" @default.
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- W2003392212 date "2011-01-01" @default.
- W2003392212 modified "2023-10-14" @default.
- W2003392212 title "Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling" @default.
- W2003392212 cites W1518835034 @default.
- W2003392212 cites W1527292906 @default.
- W2003392212 cites W1731074416 @default.
- W2003392212 cites W180124521 @default.
- W2003392212 cites W1965430573 @default.
- W2003392212 cites W1968903249 @default.
- W2003392212 cites W1973930437 @default.
- W2003392212 cites W1975984062 @default.
- W2003392212 cites W1977427723 @default.
- W2003392212 cites W1981544234 @default.
- W2003392212 cites W1983916007 @default.
- W2003392212 cites W1986429916 @default.
- W2003392212 cites W1988377666 @default.
- W2003392212 cites W1988999006 @default.
- W2003392212 cites W1989704413 @default.
- W2003392212 cites W1991843895 @default.
- W2003392212 cites W1996866382 @default.
- W2003392212 cites W2007020018 @default.
- W2003392212 cites W2011476242 @default.
- W2003392212 cites W2011810742 @default.
- W2003392212 cites W2011846070 @default.
- W2003392212 cites W2013818100 @default.
- W2003392212 cites W2017574292 @default.
- W2003392212 cites W2017663491 @default.
- W2003392212 cites W2019536096 @default.
- W2003392212 cites W2019880883 @default.
- W2003392212 cites W2021253310 @default.
- W2003392212 cites W2022126917 @default.
- W2003392212 cites W2024601786 @default.
- W2003392212 cites W2024849773 @default.
- W2003392212 cites W2026581928 @default.
- W2003392212 cites W2027609640 @default.
- W2003392212 cites W2030634993 @default.
- W2003392212 cites W2031518179 @default.
- W2003392212 cites W2031778182 @default.
- W2003392212 cites W2033486658 @default.
- W2003392212 cites W2033586478 @default.
- W2003392212 cites W2048316334 @default.
- W2003392212 cites W2050812895 @default.
- W2003392212 cites W2063493961 @default.
- W2003392212 cites W2066765735 @default.
- W2003392212 cites W2067671019 @default.
- W2003392212 cites W2072839085 @default.
- W2003392212 cites W2073595637 @default.
- W2003392212 cites W2075488686 @default.
- W2003392212 cites W2082483448 @default.
- W2003392212 cites W2087105697 @default.
- W2003392212 cites W2089692551 @default.
- W2003392212 cites W2089916504 @default.
- W2003392212 cites W2091173515 @default.
- W2003392212 cites W2095800957 @default.
- W2003392212 cites W2095905547 @default.
- W2003392212 cites W2098209017 @default.
- W2003392212 cites W2098972920 @default.
- W2003392212 cites W2100998781 @default.
- W2003392212 cites W2106196303 @default.
- W2003392212 cites W2109492293 @default.
- W2003392212 cites W2114808389 @default.
- W2003392212 cites W2117936947 @default.
- W2003392212 cites W2122231405 @default.
- W2003392212 cites W2127569438 @default.
- W2003392212 cites W2135779821 @default.
- W2003392212 cites W2138997208 @default.
- W2003392212 cites W2142268216 @default.
- W2003392212 cites W2146086400 @default.
- W2003392212 cites W2149268957 @default.
- W2003392212 cites W2149472502 @default.
- W2003392212 cites W2149779130 @default.
- W2003392212 cites W2150594596 @default.
- W2003392212 cites W2151068043 @default.
- W2003392212 cites W2152686325 @default.
- W2003392212 cites W2156941071 @default.
- W2003392212 cites W2157167939 @default.
- W2003392212 cites W2161654505 @default.
- W2003392212 cites W2183866071 @default.
- W2003392212 cites W4231771773 @default.
- W2003392212 cites W4248004095 @default.
- W2003392212 cites W4254763216 @default.
- W2003392212 doi "https://doi.org/10.1254/jphs.10r22fm" @default.
- W2003392212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21422726" @default.
- W2003392212 hasPublicationYear "2011" @default.
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