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- W2003397105 abstract "The vasoactive prostanoids—prostacyclin (PGI2) and thromboxane A2 (TxA2)-and their metabolites—6-keto-prostaglandin F1α (6-keto-PGF1α) and thromboxane B2 (TxB2), respectively—have been implicated as regulators of uteroplacental blood flow in animals. To study their roles in placental blood flow in human beings, plasma or serum samples were collected for the measurement of 6-keto-PGF1α and TxB2 from 42 women during late pregnancy on the same occasion, when placental intervillous blood flow (IVBF) was determined with 133Xe isotope method. The concentrations of 6-keto-PGF1α in plasma or those of TxB2 in plasma or serum were not related to the IVBF. The intravenous infusion of ritodrine for 1 hour up to the dose of 200 μg/min increased (p < 0.05) the plasma 6-keto-PGF1α concentrations, but caused no changes in the TxB2 levels or IVBF in seven women with premature uterine contractions. We conclude that if PGI2 and TxA2 participate in the control of placental blood flow, their changes are located in the fetoplacental unit and, thus, are not reflected by the levels of their metabolites in maternal circulation, and ritodrine may stimulate PGI2 synthesis in human beings." @default.
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- W2003397105 title "Atrial natriuretic factor is produced in trophoblasts of human term placenta" @default.
- W2003397105 doi "https://doi.org/10.1016/0143-4004(94)90086-8" @default.
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