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- W2003397264 abstract "During early ectotherm vertebrate evolution the heart was redesigned as a high pressure pump adapted to perfuse larger body sizes. To compensate the consequent higher organ complexity and heterogeneity (ventricular myoarchitecture and blood supply), conceivably the three principal cardiac cell components, the endocardium, the contractile myocardium and the epicardium recruited and diversified the cardiac NOS system for functioning not only as a major modulator, but also as a spatio-temporal integrator of heart function. In the context of NOS isoform evolution, we will use fish and amphibian paradigms to illustrate major aspects of cardiac spatial and temporal integration achieved by the NOS/NO systems. This may reveal a primordial cardiac NOS/NO function, allocating it in a wider biological framework than so far envisioned." @default.
- W2003397264 created "2016-06-24" @default.
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- W2003397264 creator A5080401382 @default.
- W2003397264 creator A5088751376 @default.
- W2003397264 date "2011-06-01" @default.
- W2003397264 modified "2023-09-29" @default.
- W2003397264 title "The evolutionary functions of cardiac NOS/NO in vertebrates tracked by fish and amphibian paradigms" @default.
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- W2003397264 doi "https://doi.org/10.1016/j.niox.2011.05.001" @default.
- W2003397264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21575737" @default.
- W2003397264 hasPublicationYear "2011" @default.
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