FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003398560> ?p ?o ?g. }

• W2003398560 endingPage "90" @default.
• W2003398560 startingPage "84" @default.
• W2003398560 abstract "Recently, we have demonstrated a direct correlation among hyperglycaemia, vascular dysfunction and eNOS post-translational regulation in non non-obese diabetic mice (NOD). Here, we evaluate the impact of two ACE-inhibitors therapy, zofenopril and enalapril in NOD mice. Insulin-dependent diabetes mellitus (IDDM) development was monitored weekly through glycosuria measurement. Zofenopril and enalapril were dosed at 0.5 mg/kg/die orally. Animals were sacrificed at different points and aortas used for western blotting or for tissue bath experiments. Bovine aortic endothelial cells in high glucose medium are treated with zofenoprilat or enalaprilat. Cells and supernatant were utilised for western blot analysis and for nitrite/nitrate determination, respectively. In ex-vivo experiments chronic administration of both drugs restored PE-induced contraction but not Isop-induced vasodilatation, however only zofenopril reduced caveolin-1 expression. In vitro, both drugs inhibited caveolin-1 expression and increased NOx production. However, zofenopril caused inhibition of both parameters at a concentration 200 fold lower than enalalpril. In vivo, zofenopril delays the onset of diabetic conditions of about 50%, and ameliorates polyuria. In conclusion our data suggest that ACE-inhibitor therapy may be useful in IDDM, in particular sulphydrylated inhibitor would display a better efficacy especially if administered early on the development of diabetes." @default.
• W2003398560 created "2016-06-24" @default.
• W2003398560 creator A5016113649 @default.
• W2003398560 creator A5033657146 @default.
• W2003398560 creator A5035545235 @default.
• W2003398560 creator A5056975864 @default.
• W2003398560 creator A5065994871 @default.
• W2003398560 creator A5066988395 @default.
• W2003398560 creator A5068424848 @default.
• W2003398560 date "2008-08-01" @default.
• W2003398560 modified "2023-10-04" @default.
• W2003398560 title "ACE-inhibition ameliorates vascular reactivity and delays diabetes outcome in NOD mice" @default.
• W2003398560 cites W180946569 @default.
• W2003398560 cites W1968788297 @default.
• W2003398560 cites W1969495146 @default.
• W2003398560 cites W1980528903 @default.
• W2003398560 cites W1984958273 @default.
• W2003398560 cites W1988413497 @default.
• W2003398560 cites W2004889850 @default.
• W2003398560 cites W2005597379 @default.
• W2003398560 cites W2011801069 @default.
• W2003398560 cites W2014830922 @default.
• W2003398560 cites W2016151911 @default.
• W2003398560 cites W2024524765 @default.
• W2003398560 cites W2034965329 @default.
• W2003398560 cites W2040929189 @default.
• W2003398560 cites W2042057376 @default.
• W2003398560 cites W2046008103 @default.
• W2003398560 cites W2048384302 @default.
• W2003398560 cites W2053820193 @default.
• W2003398560 cites W2056181314 @default.
• W2003398560 cites W2057178339 @default.
• W2003398560 cites W2064927835 @default.
• W2003398560 cites W2065860622 @default.
• W2003398560 cites W2069445171 @default.
• W2003398560 cites W2071782926 @default.
• W2003398560 cites W2073379414 @default.
• W2003398560 cites W2075569655 @default.
• W2003398560 cites W2075607851 @default.
• W2003398560 cites W2078101418 @default.
• W2003398560 cites W2095317470 @default.
• W2003398560 cites W2101302026 @default.
• W2003398560 cites W2112122483 @default.
• W2003398560 cites W2114231586 @default.
• W2003398560 cites W2122512705 @default.
• W2003398560 cites W2126355774 @default.
• W2003398560 cites W2137087929 @default.
• W2003398560 cites W2141119164 @default.
• W2003398560 cites W2157476464 @default.
• W2003398560 cites W2157884989 @default.
• W2003398560 cites W2162574861 @default.
• W2003398560 cites W2313265082 @default.
• W2003398560 cites W2323434295 @default.
• W2003398560 cites W2323549932 @default.
• W2003398560 cites W2329872997 @default.
• W2003398560 cites W2615684303 @default.
• W2003398560 cites W2769264260 @default.
• W2003398560 cites W4233562854 @default.
• W2003398560 cites W4246928487 @default.
• W2003398560 cites W82670290 @default.
• W2003398560 doi "https://doi.org/10.1016/j.vph.2008.06.002" @default.
• W2003398560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18606247" @default.
• W2003398560 hasPublicationYear "2008" @default.
• W2003398560 type Work @default.
• W2003398560 sameAs 2003398560 @default.
• W2003398560 citedByCount "10" @default.
• W2003398560 countsByYear W20033985602016 @default.
• W2003398560 countsByYear W20033985602021 @default.
• W2003398560 countsByYear W20033985602022 @default.
• W2003398560 countsByYear W20033985602023 @default.
• W2003398560 crossrefType "journal-article" @default.
• W2003398560 hasAuthorship W2003398560A5016113649 @default.
• W2003398560 hasAuthorship W2003398560A5033657146 @default.
• W2003398560 hasAuthorship W2003398560A5035545235 @default.
• W2003398560 hasAuthorship W2003398560A5056975864 @default.
• W2003398560 hasAuthorship W2003398560A5065994871 @default.
• W2003398560 hasAuthorship W2003398560A5066988395 @default.
• W2003398560 hasAuthorship W2003398560A5068424848 @default.
• W2003398560 hasConcept C126322002 @default.
• W2003398560 hasConcept C134018914 @default.
• W2003398560 hasConcept C170493617 @default.
• W2003398560 hasConcept C185592680 @default.
• W2003398560 hasConcept C202751555 @default.
• W2003398560 hasConcept C26291073 @default.
• W2003398560 hasConcept C27016395 @default.
• W2003398560 hasConcept C2775940317 @default.
• W2003398560 hasConcept C2777622882 @default.
• W2003398560 hasConcept C2777814262 @default.
• W2003398560 hasConcept C2778211319 @default.
• W2003398560 hasConcept C2778326061 @default.
• W2003398560 hasConcept C2779591629 @default.
• W2003398560 hasConcept C2780972559 @default.
• W2003398560 hasConcept C519581460 @default.
• W2003398560 hasConcept C55493867 @default.
• W2003398560 hasConcept C555293320 @default.
• W2003398560 hasConcept C55851684 @default.
• W2003398560 hasConcept C71924100 @default.
• W2003398560 hasConcept C84393581 @default.

• next