Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003402227> ?p ?o ?g. }
- W2003402227 endingPage "899" @default.
- W2003402227 startingPage "885" @default.
- W2003402227 abstract "The effectiveness of RNA interference (RNAi) in many organisms is potentiated through the signal-amplifying activity of a targeted RNA-directed RNA polymerase (RdRP) system that can convert a small population of exogenously-encountered dsRNA fragments into an abundant internal pool of small interfering RNA (siRNA). As for any biological amplification system, we expect an underlying architecture that will limit the ability of a randomly encountered trigger to produce an uncontrolled and self-escalating response. Investigating such limits in Caenorhabditis elegans, we find that feed-forward amplification is limited by biosynthetic and structural distinctions at the RNA level between (1) triggers that can produce amplification and (2) siRNA products of the amplification reaction. By assuring that initial (primary) siRNAs can act as triggers but not templates for activation, and that the resulting (secondary) siRNAs can enforce gene silencing on additional targets without unbridled trigger amplification, the system achieves substantial but fundamentally limited signal amplification." @default.
- W2003402227 created "2016-06-24" @default.
- W2003402227 creator A5012579625 @default.
- W2003402227 creator A5019036999 @default.
- W2003402227 creator A5057231025 @default.
- W2003402227 creator A5076709441 @default.
- W2003402227 date "2012-11-01" @default.
- W2003402227 modified "2023-10-14" @default.
- W2003402227 title "Protection from Feed-Forward Amplification in an Amplified RNAi Mechanism" @default.
- W2003402227 cites W1611419331 @default.
- W2003402227 cites W1932753289 @default.
- W2003402227 cites W1967763256 @default.
- W2003402227 cites W1978976893 @default.
- W2003402227 cites W1982944995 @default.
- W2003402227 cites W1988176128 @default.
- W2003402227 cites W1993907364 @default.
- W2003402227 cites W1995048848 @default.
- W2003402227 cites W2003451384 @default.
- W2003402227 cites W2013793916 @default.
- W2003402227 cites W2015167188 @default.
- W2003402227 cites W2017733353 @default.
- W2003402227 cites W2020639485 @default.
- W2003402227 cites W2023108094 @default.
- W2003402227 cites W2027573655 @default.
- W2003402227 cites W2027610589 @default.
- W2003402227 cites W2027891004 @default.
- W2003402227 cites W2031110588 @default.
- W2003402227 cites W2032093562 @default.
- W2003402227 cites W2034206562 @default.
- W2003402227 cites W2050066317 @default.
- W2003402227 cites W2057558367 @default.
- W2003402227 cites W2058499120 @default.
- W2003402227 cites W2058755281 @default.
- W2003402227 cites W2059037240 @default.
- W2003402227 cites W2062188301 @default.
- W2003402227 cites W2074106269 @default.
- W2003402227 cites W2098756183 @default.
- W2003402227 cites W2099931758 @default.
- W2003402227 cites W2101276421 @default.
- W2003402227 cites W2117991391 @default.
- W2003402227 cites W2131957545 @default.
- W2003402227 cites W2132767295 @default.
- W2003402227 cites W2134424319 @default.
- W2003402227 cites W2135031920 @default.
- W2003402227 cites W2135165188 @default.
- W2003402227 cites W2136385924 @default.
- W2003402227 cites W2136942244 @default.
- W2003402227 cites W2139122866 @default.
- W2003402227 cites W2142305917 @default.
- W2003402227 cites W2147149702 @default.
- W2003402227 cites W2149558652 @default.
- W2003402227 cites W2150080396 @default.
- W2003402227 cites W2152993806 @default.
- W2003402227 cites W2154166273 @default.
- W2003402227 cites W2154431984 @default.
- W2003402227 cites W2154841861 @default.
- W2003402227 cites W2155396586 @default.
- W2003402227 cites W2158627784 @default.
- W2003402227 cites W2167475271 @default.
- W2003402227 cites W2167557255 @default.
- W2003402227 cites W2167999293 @default.
- W2003402227 cites W2168051144 @default.
- W2003402227 cites W2171214873 @default.
- W2003402227 cites W4238861095 @default.
- W2003402227 doi "https://doi.org/10.1016/j.cell.2012.10.022" @default.
- W2003402227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3499135" @default.
- W2003402227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23141544" @default.
- W2003402227 hasPublicationYear "2012" @default.
- W2003402227 type Work @default.
- W2003402227 sameAs 2003402227 @default.
- W2003402227 citedByCount "70" @default.
- W2003402227 countsByYear W20034022272012 @default.
- W2003402227 countsByYear W20034022272013 @default.
- W2003402227 countsByYear W20034022272014 @default.
- W2003402227 countsByYear W20034022272015 @default.
- W2003402227 countsByYear W20034022272016 @default.
- W2003402227 countsByYear W20034022272017 @default.
- W2003402227 countsByYear W20034022272018 @default.
- W2003402227 countsByYear W20034022272019 @default.
- W2003402227 countsByYear W20034022272020 @default.
- W2003402227 countsByYear W20034022272021 @default.
- W2003402227 countsByYear W20034022272022 @default.
- W2003402227 countsByYear W20034022272023 @default.
- W2003402227 crossrefType "journal-article" @default.
- W2003402227 hasAuthorship W2003402227A5012579625 @default.
- W2003402227 hasAuthorship W2003402227A5019036999 @default.
- W2003402227 hasAuthorship W2003402227A5057231025 @default.
- W2003402227 hasAuthorship W2003402227A5076709441 @default.
- W2003402227 hasBestOaLocation W20034022271 @default.
- W2003402227 hasConcept C104317684 @default.
- W2003402227 hasConcept C119056186 @default.
- W2003402227 hasConcept C166703698 @default.
- W2003402227 hasConcept C172827444 @default.
- W2003402227 hasConcept C2191507 @default.
- W2003402227 hasConcept C22615655 @default.
- W2003402227 hasConcept C2778944004 @default.
- W2003402227 hasConcept C54355233 @default.
- W2003402227 hasConcept C60723119 @default.