Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003402292> ?p ?o ?g. }
- W2003402292 endingPage "2088" @default.
- W2003402292 startingPage "2083" @default.
- W2003402292 abstract "Current evidence indicates that the abnormal expression of chemokines or their receptors, such as CXC chemokine receptor‑4 (CXCR4), is positively correlated with the development, progression and metastasis of tumor cells. However, the role of CXCR4 in neuroblastoma and its response to chemotherapy remain largely unclear. In addition, forkhead box 3 (Foxp3), a transcription factor associated with T cell tolerance, is expressed in tumor cells and plays a role in the immune evasion of cancers. The present study aimed to examine the expression of CXCR4 and Foxp3 in the LAN‑5 and SK‑N‑SH neuroblastoma cell lines. The effects of chemotherapy drugs, cyclophosphamide (CTX) and pirarubicin (THP), on the expression of these two genes were also investigated. Our findings indicated that CXCR4 and Foxp3 were highly expressed in LAN‑5 and SK‑N‑SH cells. Following treatment with CTX and THP, the protein expression of CXCR4 in LAN‑5 and SK‑N‑SH cells was significantly decreased (P<0.05). The expression of Foxp3 in LAN‑5 cells was also significantly downregulated by CTX and THP treatment (P<0.05). Therefore, the high expression of CXCR4 and Foxp3 in LAN‑5 and SK‑N‑SH cells and their subsequent downregulation following administration of the chemotherapy agents suggests that the chemokine receptors, CXCR4 and Foxp3, may be involved in the metastasis and tumor evasion of neuroblastoma. Further studies should investigate the expression of CXCR4 and Foxp3 in patient samples." @default.
- W2003402292 created "2016-06-24" @default.
- W2003402292 creator A5029900406 @default.
- W2003402292 creator A5049341927 @default.
- W2003402292 creator A5056384424 @default.
- W2003402292 creator A5062613721 @default.
- W2003402292 creator A5074591909 @default.
- W2003402292 date "2014-04-03" @default.
- W2003402292 modified "2023-10-18" @default.
- W2003402292 title "Expression of CXC chemokine receptor-4 and forkhead box 3 in neuroblastoma cells and response to chemotherapy" @default.
- W2003402292 cites W1567845952 @default.
- W2003402292 cites W1965343123 @default.
- W2003402292 cites W1971986231 @default.
- W2003402292 cites W1978454126 @default.
- W2003402292 cites W1983180761 @default.
- W2003402292 cites W1985200617 @default.
- W2003402292 cites W2002695625 @default.
- W2003402292 cites W2005616249 @default.
- W2003402292 cites W2007948290 @default.
- W2003402292 cites W2010896790 @default.
- W2003402292 cites W2019090872 @default.
- W2003402292 cites W2031047333 @default.
- W2003402292 cites W2031597127 @default.
- W2003402292 cites W2034090647 @default.
- W2003402292 cites W2037244522 @default.
- W2003402292 cites W2047829498 @default.
- W2003402292 cites W2048835394 @default.
- W2003402292 cites W2049698602 @default.
- W2003402292 cites W2055012164 @default.
- W2003402292 cites W2067363319 @default.
- W2003402292 cites W2073784422 @default.
- W2003402292 cites W2078439148 @default.
- W2003402292 cites W2079790184 @default.
- W2003402292 cites W2080062408 @default.
- W2003402292 cites W2084360244 @default.
- W2003402292 cites W2112203078 @default.
- W2003402292 cites W2118727593 @default.
- W2003402292 cites W2153804081 @default.
- W2003402292 cites W4235657941 @default.
- W2003402292 cites W42400831 @default.
- W2003402292 doi "https://doi.org/10.3892/ol.2014.2028" @default.
- W2003402292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4049694" @default.
- W2003402292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24932293" @default.
- W2003402292 hasPublicationYear "2014" @default.
- W2003402292 type Work @default.
- W2003402292 sameAs 2003402292 @default.
- W2003402292 citedByCount "6" @default.
- W2003402292 countsByYear W20034022922014 @default.
- W2003402292 countsByYear W20034022922017 @default.
- W2003402292 countsByYear W20034022922019 @default.
- W2003402292 countsByYear W20034022922020 @default.
- W2003402292 crossrefType "journal-article" @default.
- W2003402292 hasAuthorship W2003402292A5029900406 @default.
- W2003402292 hasAuthorship W2003402292A5049341927 @default.
- W2003402292 hasAuthorship W2003402292A5056384424 @default.
- W2003402292 hasAuthorship W2003402292A5062613721 @default.
- W2003402292 hasAuthorship W2003402292A5074591909 @default.
- W2003402292 hasBestOaLocation W20034022921 @default.
- W2003402292 hasConcept C121608353 @default.
- W2003402292 hasConcept C126322002 @default.
- W2003402292 hasConcept C12823836 @default.
- W2003402292 hasConcept C129470790 @default.
- W2003402292 hasConcept C13373296 @default.
- W2003402292 hasConcept C203014093 @default.
- W2003402292 hasConcept C2779013556 @default.
- W2003402292 hasConcept C2779727006 @default.
- W2003402292 hasConcept C502942594 @default.
- W2003402292 hasConcept C71924100 @default.
- W2003402292 hasConcept C84913492 @default.
- W2003402292 hasConcept C86803240 @default.
- W2003402292 hasConcept C8891405 @default.
- W2003402292 hasConceptScore W2003402292C121608353 @default.
- W2003402292 hasConceptScore W2003402292C126322002 @default.
- W2003402292 hasConceptScore W2003402292C12823836 @default.
- W2003402292 hasConceptScore W2003402292C129470790 @default.
- W2003402292 hasConceptScore W2003402292C13373296 @default.
- W2003402292 hasConceptScore W2003402292C203014093 @default.
- W2003402292 hasConceptScore W2003402292C2779013556 @default.
- W2003402292 hasConceptScore W2003402292C2779727006 @default.
- W2003402292 hasConceptScore W2003402292C502942594 @default.
- W2003402292 hasConceptScore W2003402292C71924100 @default.
- W2003402292 hasConceptScore W2003402292C84913492 @default.
- W2003402292 hasConceptScore W2003402292C86803240 @default.
- W2003402292 hasConceptScore W2003402292C8891405 @default.
- W2003402292 hasIssue "6" @default.
- W2003402292 hasLocation W20034022921 @default.
- W2003402292 hasLocation W20034022922 @default.
- W2003402292 hasLocation W20034022923 @default.
- W2003402292 hasLocation W20034022924 @default.
- W2003402292 hasOpenAccess W2003402292 @default.
- W2003402292 hasPrimaryLocation W20034022921 @default.
- W2003402292 hasRelatedWork W2005666125 @default.
- W2003402292 hasRelatedWork W2055544311 @default.
- W2003402292 hasRelatedWork W2086049503 @default.
- W2003402292 hasRelatedWork W2098873911 @default.
- W2003402292 hasRelatedWork W2152930674 @default.
- W2003402292 hasRelatedWork W2155139562 @default.
- W2003402292 hasRelatedWork W2259137911 @default.