FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003402437> ?p ?o ?g. }

• W2003402437 endingPage "51" @default.
• W2003402437 startingPage "42" @default.
• W2003402437 abstract "Prostate cancer (PCa) is the second most frequent cancer among men in the European Union and the most common in the United States. Older age and a positive family history of PCa are important risk factors, but little is known about the disease aetiology. Mitochondria are involved in essential cellular pathways, some of which have been associated with tumorigenesis. We analysed the presence of sequence variants, depletion and rearrangements in the mitochondrial DNA (mtDNA) of PCa patients. Sequencing of the D-loop and genes RNR1 and 2, ND3, ND4L and ND4, and long-range and real-time PCR techniques were carried out on 51 samples (41 from patients and 10 from controls). Normal, hyperplastic or tumour samples were obtained from 17 patients. Six patients’ seminal vesicles were also investigated as an additional patient's control tissue (these structures seldom develop tumours). Neither depletion nor mtDNA rearrangements were detected. In contrast, 94 mtDNA sequence variants were identified, 9 previously unreported. The regions presenting more sequence variants were MT-DLOOP (52%), MT-RNR2 (14%) and MT-ND4 (13%). The patients’ seminal vesicles studied showed the same set of variants as the corresponding prostate, suggesting either that the pathogenic role of these particular variants is minor or that they participate in the prostatic carcinogenesis in combination with other factors absent in seminal vesicles. Five patients (29.4%) harboured eight somatic changes in the mtDNA. One affects a conserved residue and three have not been previously described. The analysis of other genes in the mtDNA molecule might demonstrate an even higher incidence of mtDNA somatic variants in these PCa patients." @default.
• W2003402437 created "2016-06-24" @default.
• W2003402437 creator A5004455611 @default.
• W2003402437 creator A5006362605 @default.
• W2003402437 creator A5019326660 @default.
• W2003402437 creator A5041833775 @default.
• W2003402437 creator A5050005275 @default.
• W2003402437 creator A5050098362 @default.
• W2003402437 creator A5072774557 @default.
• W2003402437 date "2006-03-01" @default.
• W2003402437 modified "2023-10-08" @default.
• W2003402437 title "Identification of somatic and germline mitochondrial DNA sequence variants in prostate cancer patients" @default.
• W2003402437 cites W1509720837 @default.
• W2003402437 cites W1546375972 @default.
• W2003402437 cites W1802480460 @default.
• W2003402437 cites W1969875009 @default.
• W2003402437 cites W1971824586 @default.
• W2003402437 cites W1973851166 @default.
• W2003402437 cites W1979065761 @default.
• W2003402437 cites W1985561510 @default.
• W2003402437 cites W1987641772 @default.
• W2003402437 cites W1993160802 @default.
• W2003402437 cites W1994496497 @default.
• W2003402437 cites W2011759960 @default.
• W2003402437 cites W2029269538 @default.
• W2003402437 cites W2042734644 @default.
• W2003402437 cites W2050956272 @default.
• W2003402437 cites W2067511583 @default.
• W2003402437 cites W2084897884 @default.
• W2003402437 cites W2108060570 @default.
• W2003402437 cites W2119549041 @default.
• W2003402437 cites W2141915047 @default.
• W2003402437 cites W2158615962 @default.
• W2003402437 cites W2163069284 @default.
• W2003402437 cites W2167436883 @default.
• W2003402437 cites W2319463508 @default.
• W2003402437 cites W2323868208 @default.
• W2003402437 cites W2326949580 @default.
• W2003402437 cites W4301512096 @default.
• W2003402437 doi "https://doi.org/10.1016/j.mrfmmm.2005.10.012" @default.
• W2003402437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16472830" @default.
• W2003402437 hasPublicationYear "2006" @default.
• W2003402437 type Work @default.
• W2003402437 sameAs 2003402437 @default.
• W2003402437 citedByCount "53" @default.
• W2003402437 countsByYear W20034024372012 @default.
• W2003402437 countsByYear W20034024372013 @default.
• W2003402437 countsByYear W20034024372014 @default.
• W2003402437 countsByYear W20034024372015 @default.
• W2003402437 countsByYear W20034024372016 @default.
• W2003402437 countsByYear W20034024372017 @default.
• W2003402437 countsByYear W20034024372018 @default.
• W2003402437 countsByYear W20034024372019 @default.
• W2003402437 countsByYear W20034024372021 @default.
• W2003402437 countsByYear W20034024372022 @default.
• W2003402437 countsByYear W20034024372023 @default.
• W2003402437 crossrefType "journal-article" @default.
• W2003402437 hasAuthorship W2003402437A5004455611 @default.
• W2003402437 hasAuthorship W2003402437A5006362605 @default.
• W2003402437 hasAuthorship W2003402437A5019326660 @default.
• W2003402437 hasAuthorship W2003402437A5041833775 @default.
• W2003402437 hasAuthorship W2003402437A5050005275 @default.
• W2003402437 hasAuthorship W2003402437A5050098362 @default.
• W2003402437 hasAuthorship W2003402437A5072774557 @default.
• W2003402437 hasConcept C104317684 @default.
• W2003402437 hasConcept C109825262 @default.
• W2003402437 hasConcept C121608353 @default.
• W2003402437 hasConcept C134305767 @default.
• W2003402437 hasConcept C13514818 @default.
• W2003402437 hasConcept C24586158 @default.
• W2003402437 hasConcept C2776235491 @default.
• W2003402437 hasConcept C2778112365 @default.
• W2003402437 hasConcept C2780192828 @default.
• W2003402437 hasConcept C28859421 @default.
• W2003402437 hasConcept C501734568 @default.
• W2003402437 hasConcept C51679486 @default.
• W2003402437 hasConcept C54355233 @default.
• W2003402437 hasConcept C555283112 @default.
• W2003402437 hasConcept C61053724 @default.
• W2003402437 hasConcept C86803240 @default.
• W2003402437 hasConceptScore W2003402437C104317684 @default.
• W2003402437 hasConceptScore W2003402437C109825262 @default.
• W2003402437 hasConceptScore W2003402437C121608353 @default.
• W2003402437 hasConceptScore W2003402437C134305767 @default.
• W2003402437 hasConceptScore W2003402437C13514818 @default.
• W2003402437 hasConceptScore W2003402437C24586158 @default.
• W2003402437 hasConceptScore W2003402437C2776235491 @default.
• W2003402437 hasConceptScore W2003402437C2778112365 @default.
• W2003402437 hasConceptScore W2003402437C2780192828 @default.
• W2003402437 hasConceptScore W2003402437C28859421 @default.
• W2003402437 hasConceptScore W2003402437C501734568 @default.
• W2003402437 hasConceptScore W2003402437C51679486 @default.
• W2003402437 hasConceptScore W2003402437C54355233 @default.
• W2003402437 hasConceptScore W2003402437C555283112 @default.
• W2003402437 hasConceptScore W2003402437C61053724 @default.
• W2003402437 hasConceptScore W2003402437C86803240 @default.
• W2003402437 hasIssue "1-2" @default.
• W2003402437 hasLocation W20034024371 @default.

• next