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• W2003403192 abstract "A variant of human T-lymphotropic virus type III (HTLV-III) is described that replicates but does not kill normal human T cells in vitro. This variant, designated X10-1, was derived from the genome of a cytopathic HTLV-III clone (pHXB2D) by excision of a 200-base pair segment in the 3′ region of the virus, spanning the env and 3′-orf genes. Comparable variants with 55 to 109 base pairs deleted exclusively in 3′-orf produced, in contrast, virus that was extremely cytopathic. On the basis of these findings it is concluded that the 3′-orf gene is not required for cytopathogenicity or replication of HTLV-III. In addition, the results suggest that virus replication and cytotoxicity are not intrinsically coupled. Furthermore, since clone X10-1 retains the ability to trans-activate genes linked to the viral long terminal repeats, trans-activation per se is not responsible for T-cell killing by HTLV-III. These results also raise the possibility that the carboxyl terminus of the envelope gene of HTLV-III has a direct role in T-cell killing by this virus." @default.
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• W2003403192 date "1986-08-08" @default.
• W2003403192 modified "2023-10-18" @default.
• W2003403192 title "Infectious Mutants of HTLV-III with Changes in the 3′ Region and Markedly Reduced Cytopathic Effects" @default.
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• W2003403192 doi "https://doi.org/10.1126/science.3014663" @default.
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